Methyl 3-amino-4,4,4-trifluorobutyrate
Methyl 3-amino-4,4,4-trifluorobutyrate (CAS 748746-28-3) is a trifluoromethylated amino ester with the linear formula H₂NCH(CF₃)CH₂CO₂CH₃ and a molecular weight of 171.12 g/mol. This compound serves as a valuable building block in organic synthesis, particularly in the development of novel fluorinated molecules for pharmaceutical and agrochemical research. Its unique structure makes it an attractive intermediate for introducing the trifluoromethyl group into complex organic structures.
- Synonyms
- 748746-28-3H2NCH(CF3)CH2CO2CH3
Fluorinated Pharmaceutical Intermediates
Utilised as a key building block in the synthesis of novel fluorinated active pharmaceutical ingredients (APIs). The trifluoromethyl group can significantly impact a drug's lipophilicity, metabolic stability, and binding affinity.
Agrochemical Synthesis
Serves as an intermediate in the creation of new agrochemicals, where the trifluoromethyl moiety can enhance efficacy and environmental persistence of pesticides and herbicides.
Organic Synthesis Reagent
A versatile reagent in general organic synthesis for introducing fluorinated amino ester functionalities into target molecules. Useful in creating complex organic structures for materials science and medicinal chemistry research.
| Molecular weight | 171.12 |
|---|---|
| Linear formula | H2NCH(CF3)CH2CO2CH3 |
| Assay | 95% |
| Boiling point | 50 °C/1 mmHg |
| Density | 1.293 g/mL at 25 °C |
| Refractive index | n20/D 1.378 |
| Storage temperature | 2-8°C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H334May cause allergy or asthma symptoms if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
- P342
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Transport (UN / ADR) | NA 1993 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38-43 |
| Safety statements (S) | 26-36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Methyl 3-amino-4,4,4-trifluorobutyrate used for?
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Methyl 3-amino-4,4,4-trifluorobutyrate is primarily used as a building block in organic synthesis for creating fluorinated molecules, especially in the development of pharmaceutical and agrochemical intermediates.
What is the CAS number and chemical formula for Methyl 3-amino-4,4,4-trifluorobutyrate?
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The CAS number is 748746-28-3 and the linear chemical formula is H₂NCH(CF₃)CH₂CO₂CH₃.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Methyl 3-amino-4,4,4-trifluorobutyrate with an assay of 95%. This product is supplied for research and laboratory use and is not represented as USP, BP, EP, or pharmaceutical grade.
How should Methyl 3-amino-4,4,4-trifluorobutyrate be handled safely?
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This compound is classified as a Danger with hazards including skin irritation (H315), eye irritation (H319), and respiratory irritation (H335). It may also cause respiratory irritation (H334). Appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator, must be used. Handle in a well-ventilated area.
Is Methyl 3-amino-4,4,4-trifluorobutyrate a controlled substance?
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The provided data does not indicate that Methyl 3-amino-4,4,4-trifluorobutyrate is a controlled substance.
How is Methyl 3-amino-4,4,4-trifluorobutyrate packed and shipped?
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This chemical is typically shipped according to ADR regulations as NA 1993 / PGIII. Storage at 2-8°C is recommended. For export, please contact our logistics team for specific requirements.
How can I request a quote or sample?
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To request a quote or sample, please visit the product page on the Tech Serve Solutions website and use the contact form or call our sales department.
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