Methyl 2-bromobutyrate
Methyl 2-bromobutyrate (CAS 3196-15-4) is a versatile organic building block with the molecular formula CH3CH2CHBrCOOCH3 and a molar mass of 181.03 g/mol. This ester is characterised by its bromine substituent, making it a valuable intermediate in various chemical synthesis pathways. It finds application in the preparation of complex organic molecules, particularly within pharmaceutical and fine chemical research and development.
Reformatsky Reaction Reagent
Methyl 2-bromobutyrate is utilised in Reformatsky reactions. For example, it reacts with 5-methoxy-1-indanone to synthesise racemic indene ester, and with α,α-dichloromethyl methyl ether to form (E)-2-methoxymethylene-butyric acid methyl ester.
Intermediate for Acid Chloride Synthesis
Following its use in the Reformatsky reaction to produce specific ester compounds, Methyl 2-bromobutyrate can also serve as a precursor in the synthesis of related acid chlorides, such as (E)-2-methoxymethylene-butyryl chloride.
Organic Synthesis Building Block
As a functionalised ester, it serves as a key building block in broader organic synthesis, enabling the introduction of a specific four-carbon chain with ester and reactive bromide functionalities into target molecules.
| Molecular weight | 181.03 |
|---|---|
| Linear formula | CH3CH2CHBrCOOCH3 |
| Assay | 97% |
| Boiling point | 137-138 °C/50 mmHg(lit.) |
| Density | 1.573 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.452(lit.) |
| Application | Methyl 2-bromobutyrate has been employed as reagent in the synthesis of: • racemic indene ester via Reformatsky reaction with 5-methoxy-1-indanone1• (E)-2-methoxymethylene-butyric acid methyl ester via Reformatsky reaction with α,α-dichloromethyl methyl ether in the presence of zinc dust2• (E)-2-methoxymethylene-butyryl chloride2 |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 68 °C / 154.4 °F |
| Transport (UN / ADR) | UN 3265 8 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Methyl 2-bromobutyrate used for?
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Methyl 2-bromobutyrate (CAS 3196-15-4) is primarily used as a reagent in organic synthesis, notably in Reformatsky reactions for preparing specific esters and acid chlorides. It also functions as a general building block in complex molecule synthesis.
What are the CAS number and molecular formula for Methyl 2-bromobutyrate?
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The CAS number for Methyl 2-bromobutyrate is 3196-15-4, and its molecular formula is CH3CH2CHBrCOOCH3.
What grade and purity does Tech Serve Solutions supply for Methyl 2-bromobutyrate?
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Tech Serve Solutions supplies Methyl 2-bromobutyrate with an assay of 97%. We do not represent this product as USP, BP, or EP grade; it is suitable for research and technical applications.
How should Methyl 2-bromobutyrate be handled safely?
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Methyl 2-bromobutyrate is classified as corrosive (Danger, H314). Handle with appropriate personal protective equipment, including full-face respirators, chemical-resistant gloves, and eye protection. Ensure adequate ventilation and consult the Safety Data Sheet for detailed handling procedures.
Can Tech Serve Solutions export Methyl 2-bromobutyrate internationally?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including Methyl 2-bromobutyrate. We can arrange for its export to various international destinations.
How can I request a sample or quote for Methyl 2-bromobutyrate?
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To request a sample or obtain a quote for Methyl 2-bromobutyrate, please visit the Tech Serve Solutions website or contact our sales department directly through the provided contact information.
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