Metergoline
Metergoline (CAS: 17692-51-2, Formula: C25H29N3O2) is a complex organic compound with a molecular weight of 403.52 g/mol. It functions primarily as a serotonin receptor antagonist, making it a valuable tool in neurochemical research. This compound is utilised in studies investigating the roles of various serotonin receptor subtypes in physiological and pathological processes.
- IUPAC
- N-CBZ-[(8β)-1,6-Dimethylergolin-8-yl]methylamine,[(8β)-1,6-Dimethylergolin-8-yl)methyl]carbamic acid phenylmethyl ester
Serotonin Receptor Research
Metergoline is widely employed as an antagonist in preclinical research to elucidate the functions of serotonin receptors, particularly 5-HT1A, 5-HT1B, 5-HT1D, and 5-HT2 subtypes. Its application aids in understanding neurotransmission and neurological pathways.
Neuroscience and Cell Signaling Studies
As a selective modulator of specific serotonin receptor subtypes, Metergoline is instrumental in studies focusing on cell signaling cascades and neurotransmission within the central nervous system. It helps researchers investigate the intricate mechanisms of neurological functions.
GPCR Modulator Tool
This compound serves as a G protein-coupled receptor (GPCR) modulator, specifically targeting serotonergic receptors. Its use is critical in experiments designed to probe GPCR activity and downstream signaling pathways in various biological systems.
| Molecular weight | 403.52 |
|---|---|
| Empirical formula | C25H29N3O2 |
| Solubility | 0.1 M HCl: soluble1.4 mg/mLethanol: soluble4 mg/mLH2O: insoluble |
| Storage temperature | −20°C |
| Melting point | 148-150 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H332Harmful if inhaled
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22 |
| Safety statements (S) | 36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Metergoline used for?
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Metergoline is primarily used as an antagonist in scientific research to study the roles of serotonin receptors in the central nervous system and other biological processes. It is a valuable tool in neurochemical and cell signaling research.
What is the CAS number and formula for Metergoline?
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The CAS number for Metergoline is 17692-51-2, and its molecular formula is C25H29N3O2.
What grade and purity does Tech Serve Solutions supply for Metergoline?
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Tech Serve Solutions supplies Metergoline with a purity of 98%. While it is suitable for research purposes, TSS does not represent this product as USP, BP, EP, or any other pharmacopoeial grade.
How should Metergoline be handled and stored?
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Metergoline is classified with a 'Warning' signal word and carries hazard statements H302, H312, and H332, indicating it is harmful if swallowed, in contact with skin, or if inhaled. Recommended personal protective equipment includes a dust mask (type N95), eyeshields, faceshields, and gloves. Store at -20°C.
Is Metergoline a controlled substance?
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The provided data does not indicate that Metergoline is a controlled substance.
How is Metergoline packed, shipped, and exported by TSS?
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Tech Serve Solutions packs and exports Metergoline according to standard chemical handling procedures, ensuring safe transit. Specific details for bulk or custom orders are available upon request.
How can I request a sample or quote for Metergoline?
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To request a sample or a quote for Metergoline, please contact the Tech Serve Solutions sales team through our website or direct inquiry channels.
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