Perfluorobutyryl chloride
Perfluorobutyryl chloride (CAS: 375-16-6), with the linear formula CF 3 CF 2 CF 2 COCl and a molecular weight of 232.48 g/mol, is a fluorinated organic compound. It serves as a valuable intermediate and building block in chemical synthesis. This acid halide is primarily utilised in the creation of specialised fluoropolymers and other complex organic molecules, contributing to advancements in materials science and chemical research.
- IUPAC
- Heptafluorobutyryl chloride
- Synonyms
- Heptafluorobutyryl chloride

Fluoropolymer Synthesis
Used in the preparation of novel fluoropolymers, such as ethylcellulose perfluorobutyrate, for applications like gas-exchange membranes.
Organic Synthesis Intermediate
Acts as a building block for the synthesis of various organic compounds, including heterocyclic structures like 2-perfluoroalkylbenzothiazoles.
Research and Development
Employed in laboratory settings for the development of new materials and chemical entities requiring perfluorinated moieties.
| Molecular weight | 232.48 |
|---|---|
| Linear formula | CF3CF2CF2COCl |
| Assay | 98% |
| Boiling point | 39 °C(lit.) |
| Density | 1.556 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.3(lit.) |
| Vapour pressure | 7.22 psi (20 °C) |
| Storage temperature | 2-8°C |
| Application | Perfluorobutyryl chloride has been used in the preparation of:• ethylcellulose perfluorobutyrate, non-thrombogenic novel fluoropolymer for gas-exchange membranes1• 2-perfluoroalkylbenzothiazole2 |

Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US) |
|---|---|
| Transport (UN / ADR) | UN 3265 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Perfluorobutyryl chloride used for?
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Perfluorobutyryl chloride is used as a building block in organic synthesis, particularly for preparing fluoropolymers like ethylcellulose perfluorobutyrate and compounds such as 2-perfluoroalkylbenzothiazoles.
What is the CAS number and formula for Perfluorobutyryl chloride?
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The CAS number is 375-16-6 and the linear formula is CF 3 CF 2 CF 2 COCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Perfluorobutyryl chloride with an assay of 98%. We do not represent this product as USP, BP, or EP grade; it is suitable for research and technical applications.
How should Perfluorobutyryl chloride be handled safely?
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Perfluorobutyryl chloride is classified as Danger, causing severe skin burns and eye damage (H314). Appropriate personal protective equipment, including face shields, gloves, and respiratory protection, is essential. Handle in a well-ventilated area and refer to the safety data sheet for detailed handling procedures.
How is Perfluorobutyryl chloride packed and shipped?
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The product is shipped as UN 3265, Hazard Class 8, Packing Group II, indicating it is a corrosive material. Specific packaging complies with international shipping regulations. TSS is a global supplier and exporter.
How can I request a quote or sample for Perfluorobutyryl chloride?
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To request a quote or sample, please contact our sales team through the website or by phone. Provide your contact details and the quantity required.
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