Perfluorobutyric acid
Perfluorobutyric acid (CAS: 375-22-4), with the linear formula CF3CF2CF2COOH and a molecular weight of 214.04 g/mol, is a fluorinated carboxylic acid. It is employed as a key component in chromatographic applications, notably as a mobile phase modifier in HPLC for enhanced selectivity and as an ion-pairing reagent in peptide analysis. Its properties make it a valuable building block in organic synthesis and fluorochemical research.
- IUPAC
- Edman Reagent No. 3,HFBA,Heptafluorobutyric acid,Perfluorobutyric acid
- Synonyms
- HFBAHeptafluorobutyric acidPerfluorobutyric acid375-22-4
HPLC Mobile Phase Modifier
Perfluorobutyric acid serves as a mobile phase additive in High-Performance Liquid Chromatography (HPLC) to improve the separation selectivity of various analytes, including histone proteins.
Ion-Pairing Reagent in Chromatography
It functions as an effective ion-pairing reagent for both analytical and preparative reversed-phase HPLC, particularly for the separation of underivatised peptides.
Fluorinated Building Block
As an organic fluorinated building block, it is utilised in the synthesis of more complex fluorinated organic molecules and materials.
| Molecular weight | 214.04 |
|---|---|
| Linear formula | CF3CF2CF2COOH |
| Assay | 98% |
| Boiling point | 120 °C/755 mmHg(lit.) |
| Density | 1.645 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.3(lit.) |
| Vapour pressure | ~10 mmHg (25 °C) |
| Vapour density | 7 (vs air) |
| Application | Perfluorobutyric acid was used as mobile phase modifier for enhancement of selectivity in the HPLC analysis of histone proteins1. It was used as ion pairing reagent in preparative and analytical reserved phase HPLC of underivatised peptides2. |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Transport (UN / ADR) | UN 3265 8 / PGI |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 35 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Perfluorobutyric acid used for?
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Perfluorobutyric acid is primarily used as a mobile phase modifier in HPLC for enhanced selectivity and as an ion-pairing reagent in the analysis of peptides. It also serves as a fluorinated building block in organic synthesis.
What is the CAS number and formula for Perfluorobutyric acid?
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The CAS number for Perfluorobutyric acid is 375-22-4, and its linear formula is CF3CF2CF2COOH.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Perfluorobutyric acid with an assay of 98%. This is a research-grade chemical, and TSS does not represent it as USP, BP, or EP grade.
How should Perfluorobutyric acid be handled safely?
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Perfluorobutyric acid is a corrosive substance. Handle with extreme care, using full protective equipment including a facesheild, goggles, gloves, and an appropriate respirator. Avoid contact with skin, eyes, and clothing, and ensure adequate ventilation. Refer to the Safety Data Sheet for detailed handling instructions.
How is Perfluorobutyric acid shipped and exported?
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Perfluorobutyric acid is shipped and exported in compliance with relevant transportation regulations for hazardous materials, classified under UN 3265, Class 8, Packing Group I.
How can I request a quote or sample for Perfluorobutyric acid?
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To request a quote or sample of Perfluorobutyric acid, please contact our sales team through the website or by phone, providing your specific requirements.
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