LY-294,002 hydrochloride
LY-294,002 hydrochloride (CAS: 934389-88-5) is a potent PI3K inhibitor, identified by its molecular formula C19H17NO3 · HCl and a molecular weight of 343.80. This compound is supplied as a white to off-white solid. It is widely utilised in biochemical research as a tool to investigate cell signalling pathways, particularly those involving PI3K and autophagy. Its primary application lies in its use as a research chemical for in vitro studies.
- IUPAC
- 2-(4-Morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride
- Synonyms
- 2-(4-Morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride
PI3K Inhibition
LY-294,002 hydrochloride is a well-established inhibitor of phosphatidylinositol 3-kinases (PI3K). It is used in research to explore the role of the PI3K pathway in various cellular processes, including cell growth, proliferation, and survival.
Autophagy Research
This compound serves as a valuable tool for studying autophagy, a fundamental cellular process. By inhibiting PI3K, LY-294,0002 hydrochloride can modulate autophagic flux, making it useful for investigating its mechanisms and implications in disease.
Cell Signalling Studies
As a modulator of a key signalling pathway, LY-294,002 hydrochloride is employed in cell biology to dissect complex signalling networks. It helps researchers understand how PI3K activity influences downstream events and cellular responses.
Cancer Research
The PI3K pathway is frequently dysregulated in cancer. LY-294,002 hydrochloride is used in preclinical cancer research to investigate the therapeutic potential of PI3K inhibition and to study its effects on cancer cell behaviour.
| Molecular weight | 343.80 |
|---|---|
| Empirical formula | C19H17NO3 · HCl |
| Assay | ≥98% (HPLC) |
| Form | solid |
| Colour | white to off-white |
| Solubility | DMSO: >5 mg/mLH2O: insoluble |
| Storage temperature | 2-8°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is LY-294,002 hydrochloride used for?
+
LY-294,002 hydrochloride is primarily used as a research chemical for investigating PI3K signalling pathways, cell growth, proliferation, survival, and autophagy in vitro.
What is the CAS number and formula for LY-294,002 hydrochloride?
+
The CAS number for LY-294,002 hydrochloride is 934389-88-5, and its empirical formula is C19H17NO3 · HCl.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies LY-294,002 hydrochloride with a purity of ≥98% (HPLC). This product is intended for research and laboratory use only and is not represented as USP, BP, EP, or pharmaceutical grade.
What are the safety and handling precautions for LY-294,002 hydrochloride?
+
When handling LY-294,002 hydrochloride, it is essential to use appropriate personal protective equipment, including eyeshields, gloves, and a type N95 (US) or type P1 (EN143) respirator filter. The compound is classified with WGK Germany 3.
How is LY-294,002 hydrochloride shipped and exported?
+
Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, pharmaceutical intermediates, and laboratory reagents, adhering to all necessary regulations for international shipping.
How can I request a quote or sample of LY-294,002 hydrochloride?
+
Please contact our sales team or use the online enquiry form on our website to request a quote or a sample of LY-294,002 hydrochloride.
▶ Related products
![(±)-(E)-4-Ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide (C8H13N3O4) — chemical structure, CAS 138472-01-2; Biochemicals & Reagents, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F138472-01-2.png&w=3840&q=75)
(±)-(E)-4-Ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide
C8H13N3O4
Biochemicals & Reagents![(±)-(E)-4-Ethyl-2-[(Z)-hydroxyimino]-5-nitro-3-hexen-1-yl-nicotinamide (C14H18N4O4) — chemical structure, CAS 162626-99-5; Biochemicals & Reagents, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F162626-99-5.png&w=3840&q=75)
(±)-(E)-4-Ethyl-2-[(Z)-hydroxyimino]-5-nitro-3-hexen-1-yl-nicotinamide
C14H18N4O4
Biochemicals & Reagents
(±)-2,5-Dimethoxy-4-bromoamphetamine hydrobromide
Biochemicals & Reagents
(±)-2-(p-Methoxyphenoxy)propionic acid
C10H12O4
Biochemicals & Reagents
(±)-2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene hydrobromide
C10H13NO2·HBr
Biochemicals & Reagents
(±)-2-Hydroxydecanoic acid
C10H20O3
Biochemicals & Reagents
(±)-3-Hydroxydecanoic acid
C10H20O3
Biochemicals & Reagents
(±)-3-Hydroxyoctanoic acid
C8H16O3
Biochemicals & Reagents▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis