Chk2 Inhibitor II hydrate
Chk2 Inhibitor II hydrate (CAS: 516480-79-8) is a chemical compound with the molecular formula C20H14ClN3O2 · xH2O. This off-white to tan solid, with a molecular weight of 363.80 (anhydrous basis), functions as a specific inhibitor of Checkpoint Kinase 2 (CHEK2). It is valuable in biochemical research, particularly in studies related to cell cycle control, DNA damage response, and cancer biology.
- IUPAC
- 2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide hydrate
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Cell Cycle Regulation Studies
Chk2 Inhibitor II hydrate is employed in research to investigate the intricate mechanisms of cell cycle progression and the role of Chk2 in DNA damage checkpoints. Its specific inhibitory action allows for precise manipulation of cellular pathways.
DNA Damage Response Research
This compound serves as a critical tool for understanding how cells respond to DNA damage. Researchers utilize it to explore the signaling cascades mediated by Chk2, which are vital for genomic stability and preventing oncogenesis.
Cancer Biology Investigations
As Chk2 plays a significant role in tumour suppression, Chk2 Inhibitor II hydrate is used in studies aiming to elucidate its function in various cancer types. This aids in the development of potential therapeutic strategies targeting this kinase.
Neuroscience Research
The compound's involvement in cell signaling pathways extends to neuroscience, where it may be used to study neuronal development, survival, and response to stress or damage.
| Molecular weight | 363.80 (anhydrous basis) |
|---|---|
| Empirical formula | C20H14ClN3O2 · xH2O |
| Assay | ≥98% (HPLC) |
| Form | solid |
| Colour | off-white to tan |
| Solubility | DMSO: >10 mg/mL |
| Storage temperature | 2-8°C |
| Gene Information | human ... CHEK2(11200) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Chk2 Inhibitor II hydrate used for?
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Chk2 Inhibitor II hydrate is used in biochemical research for studying cell cycle regulation, DNA damage response, and cancer biology, particularly investigating the function of Checkpoint Kinase 2 (CHEK2).
What are the CAS number and molecular formula?
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The CAS number for the anhydrous form is 516480-79-8. The empirical formula is C20H14ClN3O2 · xH2O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Chk2 Inhibitor II hydrate with an assay of ≥98% (HPLC). This is a research-grade chemical and is not represented as USP, BP, EP, or any other pharmacopoeia grade.
How should Chk2 Inhibitor II hydrate be handled and stored?
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Chk2 Inhibitor II hydrate is a solid with a WGK Germany classification of 3. It should be stored at 2-8°C. Handle with appropriate personal protective equipment, avoiding contact with skin and eyes, and ensure adequate ventilation.
How is this product packed, shipped, and exported?
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Tech Serve Solutions professionally packs, ships, and exports fine chemicals globally, adhering to all relevant regulations for safe and secure transport.
How can I request a sample or quote?
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To request a sample or a quote for Chk2 Inhibitor II hydrate, please contact our sales department through the website or by phone.
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