Trimethyl(trifluoromethyl)silane
Trimethyl(trifluoromethyl)silane (CAS: 81290-20-2), with the linear formula (CH3)3SiCF3 and a molecular weight of 142.19 g/mol, is a versatile organosilicon compound. It serves as a key reagent in organic synthesis, particularly for introducing the trifluoromethyl group (CF3) into various molecules. This compound is widely utilised in chemical synthesis and C-C bond formation due to its reactivity and utility in creating fluorinated organic compounds for research and development.
- IUPAC
- (Trifluoromethyl)trimethylsilane,Ruppert’s Reagent,TFMTMS
- Synonyms
- (Trifluoromethyl)trimethylsilaneRuppert’s ReagentTFMTMS
Trifluoromethylation Reagent
Trimethyl(trifluoromethyl)silane is extensively employed as a nucleophilic trifluoromethylating agent in organic synthesis. It facilitates the introduction of the CF3 group onto electrophilic carbon centres, enabling the synthesis of fluorinated organic molecules.
C-C Bond Formation
This silane is instrumental in the formation of new carbon-carbon bonds through various synthetic methodologies. Its ability to act as a source of the trifluoromethyl anion makes it valuable for constructing complex organic architectures.
Fluorinated Compound Synthesis
It is a crucial building block for preparing a wide array of fluorinated organic compounds. These compounds often exhibit unique properties valuable in pharmaceuticals, agrochemicals, and materials science.
Research and Development
In laboratory settings, Trimethyl(trifluoromethyl)silane is a commonly used reagent for exploring new synthetic routes and developing novel fluorinated molecules, supporting innovation in chemical research.
| Molecular weight | 142.19 |
|---|---|
| Linear formula | (CH3)3SiCF3 |
| Assay | 99% |
| Grade | purum |
| Boiling point | 54-55 °C(lit.) |
| Density | 0.962 g/mL at 20 °C(lit.) |
| Concentration | 0.5 M in THF |
| Vapour pressure | 10.98 psi (55 °C)2.8 psi (20 °C) |
| Storage temperature | 2-8°C |
Hazard statements
- H225Highly flammable liquid and vapour
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US) |
|---|---|
| Flash point | -17 °C / 1.4 °F |
| Transport (UN / ADR) | UN 1993BF 3 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F |
| Risk statements (R) | 11 |
| Safety statements (S) | 16-33 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Trimethyl(trifluoromethyl)silane used for?
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Trimethyl(trifluoromethyl)silane is primarily used as a trifluoromethylation reagent in organic synthesis for C-C bond formation and the synthesis of fluorinated compounds in research and development.
What is the CAS number and formula for Trimethyl(trifluoromethyl)silane?
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The CAS number for Trimethyl(trifluoromethyl)silane is 81290-20-2, and its linear formula is (CH3)3SiCF3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Trimethyl(trifluoromethyl)silane with a purity of 99% (purum grade). We do not represent this product as USP, BP, or EP grade.
How should Trimethyl(trifluoromethyl)silane be handled safely?
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Trimethyl(trifluoromethyl)silane is highly flammable (H225) and requires careful handling. Store in a cool, well-ventilated place away from ignition sources. Use appropriate personal protective equipment, including eyeshields, gloves, and respiratory protection, as indicated by the safety data sheet.
How is Trimethyl(trifluoromethyl)silane packed and exported?
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Trimethyl(trifluoromethyl)silane is supplied in appropriate packaging for safe transport and export, adhering to international shipping regulations. Please contact us for specific details regarding your region.
How can I request a sample or quote for Trimethyl(trifluoromethyl)silane?
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To request a sample or a quotation for Trimethyl(trifluoromethyl)silane, please contact our sales department through the website or by phone. We will respond promptly to your inquiry.
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