Trimethyl(propargyl)silane
Trimethyl(propargyl)silane (CAS: 13361-64-3; Formula: HC≡CCH₂Si(CH₃)₃) is an organosilicon compound with a molar mass of 112.24 g/mol. This versatile chemical serves as a valuable building block in organic synthesis. Its terminal alkyne functionality, protected by a trimethylsilyl group, allows for controlled reactions and further functionalization in the creation of complex organic molecules.
- IUPAC
- 2-Propynyl-trimethylsilane,3-(Trimethylsilyl)propyne
- Synonyms
- 2-Propynyl-trimethylsilane3-(Trimethylsilyl)propyne

Organic Synthesis Intermediate
Trimethyl(propargyl)silane is widely employed as a synthetic intermediate in the construction of complex organic frameworks. Its structure allows for selective modifications, making it useful in multi-step syntheses.
Building Block for Heterocycles
This compound can be utilized in the synthesis of various heterocyclic compounds. The propargyl group can participate in cyclization reactions, leading to diverse ring systems.
Precursor for Functionalized Alkynes
The trimethylsilyl group can be selectively removed under specific conditions, revealing a terminal alkyne ready for further reactions such as Sonogashira coupling or click chemistry.
| Molecular weight | 112.24 |
|---|---|
| Linear formula | HC≡CCH2Si(CH3)3 |
| Boiling point | 91-93 °C(lit.) |
| Density | 0.753 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.413(lit.) |
| Storage temperature | −20°C |
| Contains / stabiliser | 500 ppm BHT as stabilizer≤20% trimethylallenylsilane (in equilibrium) |


Hazard statements
- H225Highly flammable liquid and vapour
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | -5 °C / 23 °F |
| Transport (UN / ADR) | UN 1993BF 3 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,Xi |
| Risk statements (R) | 11-36/37/38 |
| Safety statements (S) | 16-26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Trimethyl(propargyl)silane used for?
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Trimethyl(propargyl)silane is primarily used as a building block and intermediate in organic synthesis for constructing complex molecules and functionalized alkynes.
What are the CAS number and chemical formula for Trimethyl(propargyl)silane?
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The CAS number is 13361-64-3, and the chemical formula is HC≡CCH₂Si(CH₃)₃.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Trimethyl(propargyl)silane at a technical/research grade. We do not represent this product as USP, BP, or EP grade.
How should Trimethyl(propargyl)silane be handled safely?
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Trimethyl(propargyl)silane is a flammable liquid and vapour (H225). It is a skin irritant (H315), eye irritant (H319), and may cause respiratory irritation (H335). Handle with appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator, in a well-ventilated area away from ignition sources.
Is Trimethyl(propargyl)silane flammable?
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Yes, Trimethyl(propargyl)silane is flammable with a flash point of -5 °C (23 °F) and is classified as H225: Highly flammable liquid and vapour.
How is Trimethyl(propargyl)silane packed and shipped?
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Trimethyl(propargyl)silane is typically packed in suitable containers for hazardous materials and can be exported globally by Tech Serve Solutions in compliance with transport regulations.
How can I request a quote or sample for Trimethyl(propargyl)silane?
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To request a quote or sample, please contact our sales department through the website or by phone, providing your specific requirements.
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