LY-165,163
LY-165,163 (CAS: 1814-64-8) is an off-white solid compound with the molecular formula C19H22F3N3 and a molecular weight of 349.39. As a research chemical, it is recognised for its role as an agonist, particularly within the fields of cell signalling, neuroscience, and GPCR modulation. Its solubility profile includes free solubility in ethanol and slight solubility in 0.1 M HCl, while being insoluble in water, making it suitable for specific laboratory applications.
- IUPAC
- 4-[2-[4-[3-(Trifluoromethyl)phenyl]-1-piperazinyl]ethyl]benzeneamine,p-Aminophenethyl-m-trifluoromethylphenyl piperazine,PAPP
- Synonyms
- 4-[2-[4-[3-(Trifluoromethyl)phenyl]-1-piperazinyl]ethyl]benzeneaminep-Aminophenethyl-m-trifluoromethylphenyl piperazinePAPP

Neuroscience Research
LY-165,163 serves as a valuable tool for investigating neurotransmission and the function of serotonin receptors (e.g., HTR1A, HTR1D) in the central nervous system.
GPCR Modulation Studies
This compound is employed in research focused on G protein-coupled receptors (GPCRs), aiding in the understanding of cellular signaling pathways and the development of targeted therapeutics.
Bioactive Small Molecule Research
As a bioactive small molecule, LY-165,163 is utilised in biochemical assays and screening platforms to explore biological activity and potential therapeutic targets.
| Molecular weight | 349.39 |
|---|---|
| Empirical formula | C19H22F3N3 |
| Form | solid |
| Colour | off-white |
| Solubility | 0.1 M HCl: slightly solubleH2O: insolubleethanol: freely soluble |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... HTR1A(3350), HTR1D(3352) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is LY-165,163 primarily used for?
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LY-165,163 is primarily used as a research chemical, acting as an agonist in studies related to neuroscience, cell signalling, and GPCR modulation.
What are the CAS number and molecular formula for LY-165,163?
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The CAS number for LY-165,163 is 1814-64-8, and its molecular formula is C19H22F3N3.
What grade and purity does Tech Serve Solutions supply for LY-165,163?
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Tech Serve Solutions supplies LY-165,163 as a technical/research grade chemical. We do not represent it as USP, BP, EP, or any other pharmacopoeia grade unless explicitly stated in the product specifications.
What are the key safety considerations when handling LY-165,163?
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When handling LY-165,163, it is essential to use appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter should be used. The compound has a WGK Germany rating of 3, indicating it is hazardous to water.
How is LY-165,163 typically packed and shipped?
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LY-165,163 is carefully packed in compliance with international shipping regulations for hazardous materials and is exported globally by Tech Serve Solutions.
How can I request a sample or quote for LY-165,163?
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To request a sample or a quote for LY-165,163, please contact the Tech Serve Solutions sales team through our website or by phone.
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