Loratadine

CAS 79794-75-5C22H23N2O2ClBiochemicals & Reagents

Loratadine (CAS: 79794-75-5), with the molecular formula C22H23N2O2Cl and a molecular weight of 382.88 g/mol, is a bioactive small molecule commonly supplied as a white powder. It functions as a histamine antagonist. This compound is recognised for its therapeutic applications and is a subject of research in cell signaling and neuroscience, particularly in the study of GPCR modulators and neurotransmission.

IUPAC: 4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene-1-piperidinecarboxylic acid ethyl ester,Loratidine

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Loratadine (C22H23N2O2Cl) — chemical structure, CAS 79794-75-5; Life Science, fine chemical supplied by Tech Serve Solutions

AntagonistsBioactive Small MoleculesBiochemicals and ReagentsCell BiologyGPCR ModulatorsGPCR ProteinsModulators and AntibodiesHistaminergicsHistaminergics - AntagonistsNeuroscience

01 /Applications

Histamine Antagonist Research

Loratadine is utilised as a selective, long-acting peripheral H1 receptor antagonist. Its properties make it valuable for studying histamine pathways and their role in various physiological processes.

Drug Candidate Research

As an approved therapeutic, Loratadine serves as a reference compound or starting point for the development of novel antihistaminic agents and other therapeutics targeting related pathways.

GPCR Modulation Studies

This compound is employed in research focused on G protein-coupled receptors (GPCRs), particularly those involved in cellular signaling and neurological functions, due to its interaction with H1 receptors.

Biochemical and Reagent Use

Loratadine is supplied as a biochemical reagent for laboratory use in investigating biological mechanisms, cell biology, and neuroscience research areas.

02 /Properties

Molecular weight	382.88
Empirical formula	C22H23N2O2Cl
Assay	≥98% (HPLC)
Form	powder
Colour	white
Solubility	DMSO: soluble50 mg/mLH2O: insoluble
Storage temperature	2-8°C

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	2

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

79794-75-5

MDL number

MFCD00672869

PubChem substance

24278525

05 /Additional specifications

Gene Information	human ... CYP3A4(1576), HRH1(3269), KCNH1(3756), KCNH2(3757), PTAFR(5724)rat ... Hrh1(24448)

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is Loratadine used for?

Loratadine is primarily used as a selective, long-acting peripheral H1 receptor antagonist, with applications in therapeutic research, drug candidate development, GPCR modulation studies, and as a general biochemical reagent for laboratory investigations.

What are the CAS number and molecular formula for Loratadine?

The CAS number for Loratadine is 79794-75-5, and its molecular formula is C22H23N2O2Cl.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Loratadine with a purity of ≥98% (HPLC). We do not represent this product as USP, BP, or EP grade; it is supplied as a technical/research grade chemical.

What are the safety and handling requirements for Loratadine?

Handling Loratadine requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. The compound has a WGK Germany classification of 2.

How is Loratadine packed, shipped, and exported?

Loratadine is typically supplied as a white powder and stored at 2-8°C. Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, ensuring compliant packing, shipping, and export procedures.

How can I request a quote or sample for Loratadine?

To request a quote or sample for Loratadine, please contact our sales team through our website or by direct inquiry, providing the product name and CAS number.