2-Amino-4-tert-butylphenol
2-Amino-4-tert-butylphenol (CAS 1199-46-8) is a substituted phenol with the linear formula (CH₃)₃CC₆H₃(NH₂)OH and a molecular weight of 165.23 g/mol. This organic building block is frequently employed in chemical synthesis for the preparation of more complex molecules. Its structure lends itself to various derivatizations, making it a valuable intermediate in research and development settings.
Preparation of Schiff Bases and Ligands
2-Amino-4-tert-butylphenol serves as a key precursor for synthesising Schiff bases, such as 4-tert-butyl-2-[(2-pyridylmethylene)amino]phenol. These compounds can act as ligands in coordination chemistry.
Organocatalyst Development
It has been utilised in the synthesis of prolinamides, which function as efficient hydrophobic organocatalysts. These catalysts are particularly noted for their application in direct asymmetric aldol reactions conducted in aqueous media.
Synthesis of Salophene Derivatives
The compound is a required intermediate in the synthesis of N-(2-hydroxy-4-tert-butylphenyl)-acetamide. This intermediate is subsequently used in the preparation of UO₂ salophene complexes, which are of interest in materials science.
| Molecular weight | 165.23 |
|---|---|
| Linear formula | (CH3)3CC6H3(NH2)OH |
| Assay | 98% |
| Application | 2-Amino-4-tert-butylphenol was used in the preparation of:• 4-tert-butyl-2-[(2-pyridylmethylene)amino]phenol1• prolinamides, an efficient hydrophobic organocatalyst for direct asymmetric aldol reaction in water2• N-(2-hydroxy-4-tert-butylphenyl)-acetamide, required for the synthesis of UO2 salophenes3 |
| Melting point | 160-163 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 26-37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Amino-4-tert-butylphenol primarily used for?
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2-Amino-4-tert-butylphenol is primarily used as a building block and intermediate in organic synthesis, including the preparation of Schiff bases, organocatalysts, and salophene derivatives.
What are the CAS number and linear formula for 2-Amino-4-tert-butylphenol?
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The CAS number for 2-Amino-4-tert-butylphenol is 1199-46-8, and its linear formula is (CH₃)₃CC₆H₃(NH₂)OH.
What grade and purity does Tech Serve Solutions supply for 2-Amino-4-tert-butylphenol?
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Tech Serve Solutions supplies 2-Amino-4-tert-butylphenol with an assay of 98%. We do not represent this product as USP, BP, EP, or for pharmaceutical, nutraceutical, or food use.
How should 2-Amino-4-tert-butylphenol be handled safely?
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2-Amino-4-tert-butylphenol is harmful if swallowed, in contact with skin, and if inhaled. It causes skin and serious eye irritation and may cause respiratory irritation. Appropriate personal protective equipment, including a dust mask type N95 (US), eyeshields, and gloves, should be used. Handle in a well-ventilated area.
Is 2-Amino-4-tert-butylphenol exported by Tech Serve Solutions?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including 2-Amino-4-tert-butylphenol.
How can I request a sample or quote for 2-Amino-4-tert-butylphenol?
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To request a sample or obtain a quote for 2-Amino-4-tert-butylphenol, please contact our sales department through the website or by phone.
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