Lofepramine hydrochloride

CAS 26786-32-3C26H28Cl2N2OBiochemicals & Reagents

Lofepramine hydrochloride (CAS: 26786-32-3), with the molecular formula C26H28Cl2N2O and a molecular weight of 455.42 g/mol, is supplied as an off-white solid. This compound is recognised for its role as a biogenic amine transport inhibitor and is utilised in research settings for studies related to cell signaling, neuroscience, and neurotransmission. Its solubility profile indicates good solubility in DMSO and insolubility in water, making it suitable for specific in vitro applications.

IUPAC: N-(4-Chlorobenzoylmethyl)-3-(10,11-dihydro-5h-dibenz[b,f]azepin-5-yl)-n-methylpropylamine hydrochloride

Email us

Lofepramine hydrochloride (C26H28Cl2N2O) — chemical structure, CAS 26786-32-3; Life Science, fine chemical supplied by Tech Serve Solutions

Bioactive Small MoleculesBiochemicals and ReagentsCell BiologyGPCR ModulatorsGPCR ProteinsModulators and AntibodiesMerckNeuroscienceNeurotransmissionNeurotransmitters

01 /Applications

Neuroscience Research

Lofepramine hydrochloride serves as a valuable tool in neuroscience research, particularly for investigating mechanisms of neurotransmission and the function of biogenic amine transporters. Its use aids in understanding complex cellular signaling pathways within the nervous system.

Biochemical Studies

As a bioactive small molecule, this compound is employed in biochemical studies to explore cellular functions and interactions. It is particularly relevant for research involving membrane protein biology and GPCR modulation.

Drug Candidate Investigation

This chemical is categorised as an Approved Therapeutic/Drug Candidate, making it a subject of interest in preclinical research and drug discovery. Its properties are studied to understand potential therapeutic applications.

02 /Properties

Molecular weight	455.42
Empirical formula	C26H28Cl2N2O
Assay	≥98% (HPLC)
Form	solid
Colour	off-white
Solubility	DMSO: ~24 mg/mLH2O: insoluble
Storage temperature	2-8°C

03 /Safety & handling

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

Warning

Hazard statements

H302Harmful if swallowed
H335May cause respiratory irritation
H413May cause long-lasting harmful effects to aquatic life

Precautionary statements

P261Avoid breathing dust, fume, gas or vapours

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	2
Hazard codes (EU)	Xn
Risk statements (R)	22-37-53
Safety statements (S)	22-24/25-26-28-36/37/39-38

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

26786-32-3

MDL number

MFCD00941486

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Lofepramine hydrochloride used for?

Lofepramine hydrochloride is used in research settings for studying neuroscience, cell signaling, neurotransmission, and as a biogenic amine transport inhibitor. It is also recognised as an approved therapeutic/drug candidate.

What are the CAS number and formula for Lofepramine hydrochloride?

The CAS number for Lofepramine hydrochloride is 26786-32-3, and its molecular formula is C26H28Cl2N2O.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Lofepramine hydrochloride with an assay of ≥98% (HPLC). This product is intended for research and laboratory use only and is not supplied as USP, BP, or EP grade.

What are the safety considerations for handling Lofepramine hydrochloride?

Lofepramine hydrochloride is classified as a GHS07 substance with a 'Warning' signal word. It carries hazard statements H302 (Harmful if swallowed) and H335 (May cause respiratory irritation), and H413 (May cause long lasting harmful effects to aquatic life). Appropriate personal protective equipment, including eyeshields, gloves, and a type N95 respirator filter, should be used. Handle in a well-ventilated area.

How is Lofepramine hydrochloride packaged and shipped?

Lofepramine hydrochloride is typically supplied as an off-white solid and stored at 2-8°C. We ensure compliant packaging and export procedures for all our chemical products.