L-Buthionine-sulfoximine
L-Buthionine-sulfoximine (CAS: 83730-53-4), with the molecular formula C8H18N2O3S and a molecular weight of 222.31 g/mol, is a biochemical reagent. It functions as an irreversible inhibitor of glutathione synthetase. This compound is primarily utilised in research settings to induce experimental glutathione deficiency, enabling the investigation of glutathione's various roles in cellular processes and biological systems.
- IUPAC
- L-BSO
Experimental Glutathione Deficiency Induction
L-Buthionine-sulfoximine is employed to experimentally deplete cellular glutathione levels. This allows researchers to study the consequences of glutathione depletion and understand its essential functions in cellular defence and metabolism.
Enzyme Inhibition Studies
As a potent inhibitor of glutathione synthetase, L-Buthionine-sulfoximine is used to investigate the activity and regulation of enzymes involved in the glutathione biosynthesis pathway.
Cellular Process Investigation
By inducing glutathione deficiency, this reagent aids in exploring the involvement of glutathione in a wide array of cellular processes, including oxidative stress response, drug metabolism, and immune function.
| Molecular weight | 222.31 |
|---|---|
| Empirical formula | C8H18N2O3S |
| Assay | ≥97% (TLC) |
| Solubility | H2O: soluble50 mg/mL, clear, colorless to faintly yellow |
| Optical activity | [α]20/D +33±1°, c = 1% in 1 M HCl |
| Storage temperature | 2-8°C |
| Application | Used to induce experimental glutathione deficiency, to investigate roles of glutathione in cellular processes.1 |
| Melting point | 224-228 °C (dec.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is L-Buthionine-sulfoximine used for?
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L-Buthionine-sulfoximine is used in research to experimentally induce glutathione deficiency, facilitating the study of glutathione's roles in cellular processes.
What are the CAS number and formula for L-Buthionine-sulfoximine?
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The CAS number for L-Buthionine-sulfoximine is 83730-53-4, and its empirical formula is C8H18N2O3S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies L-Buthionine-sulfoximine with an assay of ≥97% (TLC). TSS does not represent this product as USP, BP, EP, or other pharmacopoeia grades.
What are the safety and handling considerations for L-Buthionine-sulfoximine?
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Handling L-Buthionine-sulfoximine requires appropriate personal protective equipment, including eyeshields, gloves, and a type N95 (US) or P1 (EN143) respirator filter. The compound is classified with WGK Germany 3, indicating a high hazard to water.
Is L-Buthionine-sulfoximine a controlled substance?
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There is no indication in the provided data that L-Buthionine-sulfoximine is a controlled substance.
How is L-Buthionine-sulfoximine supplied and exported?
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L-Buthionine-sulfoximine is typically stored at 2-8°C. As a global supplier, Tech Serve Solutions exports this chemical worldwide following all appropriate regulations.
How can I request a quote or sample for L-Buthionine-sulfoximine?
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To request a quote or sample for L-Buthionine-sulfoximine, please contact our sales department through the Tech Serve Solutions website or via the provided contact information.
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