KN-93
KN-93 (CAS 139298-40-1), with the empirical formula C26H29ClN2O4S · H3PO4 and a molecular weight of 599.03, is a bioactive small molecule. This compound is recognised for its role as an inhibitor, particularly targeting Calcium/Calmodulin-Dependent Protein Kinase (CaMK) and Calmodulin-dependent Protein Kinase II. Its applications span cell biology and cell signaling research, aiding investigations into kinase/phosphatase pathways and neuroscience.
- IUPAC
- N-[2-[N-(4-Chlorocinnamyl)-N-methylaminomethyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide phosphate salt,N-[2-[[[3-(4′-Chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4′-methoxybenzenesulfonamide phosphate salt
Calcium/Calmodulin-Dependent Protein Kinase (CaMK) Inhibition
KN-93 acts as an inhibitor of CaMK, a crucial enzyme involved in various cellular processes including learning and memory. It is used in research to study the downstream effects of CaMK inhibition in neuronal function and other biological systems.
Calmodulin-dependent Protein Kinase II (CaMKII) Research
This compound is a selective inhibitor of CaMKII, a serine/threonine-specific protein kinase essential for synaptic plasticity and memory formation. Researchers utilise KN-93 to elucidate the specific roles of CaMKII in cellular signaling pathways.
Cell Biology and Signaling Studies
As a tool compound in cell biology, KN-93 aids in the investigation of cellular signaling cascades. Its ability to modulate kinase activity makes it valuable for understanding signal transduction pathways critical for cell growth, differentiation, and function.
Neuroscience Research
KN-93 is employed in neuroscience to explore the physiological roles of CaMK pathways in neuronal function. Its inhibitory properties help researchers dissect the molecular mechanisms underlying neurological processes.
| Molecular weight | 599.03 |
|---|---|
| Empirical formula | C26H29ClN2O4S · H3PO4 |
| Assay | ≥98% (HPLC) |
| Colour | white |
| Solubility | DMSO: soluble1 mg/mLH2O: soluble |
| Storage temperature | 2-8°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is KN-93 primarily used for?
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KN-93 is primarily used as an inhibitor of Calcium/Calmodulin-Dependent Protein Kinase (CaMK) and Calmodulin-dependent Protein Kinase II (CaMKII), making it valuable for research in cell biology, cell signaling, and neuroscience.
What are the CAS number and formula for KN-93?
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The CAS number for KN-93 is 139298-40-1, and its empirical formula is C26H29ClN2O4S · H3PO4.
What grade and purity does Tech Serve Solutions supply for KN-93?
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Tech Serve Solutions supplies KN-93 with an assay of ≥98% (HPLC). We do not represent this product as USP, BP, EP, or any other pharmacopoeial grade.
How should KN-93 be handled and stored?
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KN-93 should be handled with appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. Store KN-93 at 2-8°C.
Is KN-93 a controlled substance?
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The provided data does not indicate that KN-93 is a controlled substance.
How is KN-93 typically packaged and shipped?
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KN-93 is packaged in accordance with industry standards for chemical reagents and is available for export globally. Specific packaging details can be provided upon request.
How can I request a sample or quote for KN-93?
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To request a sample or quote for KN-93, please contact our sales team through the website or via direct inquiry, referencing product code 139298-40-1.
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