KN-62

CAS 127191-97-3C38H35N5O6S2Biochemicals & Reagents

KN-62 (CAS: 127191-97-3), with the empirical formula C38H35N5O6S2 and a molecular weight of 721.84 g/mol, is a yellow powder. This compound is primarily utilised as a selective inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII). It finds applications in biochemical research, particularly in studies involving cell signalling, neuroscience, and enzyme inhibition, serving as a valuable tool for investigating these complex biological pathways.

IUPAC: (S)-5-Isoquinolinesulfonic acid 4-[2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester,1-[N,O-bis(5-Isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine

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KN-62 (C38H35N5O6S2) — chemical structure, CAS 127191-97-3; Life Science, fine chemical supplied by Tech Serve Solutions

A to CBioactive Small MoleculesBiochemicals and ReagentsCell BiologyEnzyme InhibitorsEnzyme Inhibitors by EnzymeEnzymesInhibitorsand SubstratesKinase/Phosphatase Biology

01 /Applications

CaMKII Inhibition

KN-62 is a potent and selective inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII). This property makes it invaluable for researchers studying the role of CaMKII in various cellular processes, including synaptic plasticity and memory formation.

Cell Signalling Research

As an inhibitor of a key kinase in intracellular signalling cascades, KN-62 is employed in cell biology to dissect signalling pathways. Its use helps elucidate the downstream effects of CaMKII activation or inhibition in different cell types.

Neuroscience Studies

Given the critical role of CaMKII in neuronal function and plasticity, KN-62 is frequently used in neuroscience research. It aids in understanding the molecular mechanisms underlying learning, memory, and neurological disorders.

Enzyme Inhibitor Research

KN-62 serves as a standard research tool for investigating enzyme kinetics and inhibitor profiling within the broader field of enzyme inhibitors. Researchers utilise it to study the specific interactions and effects of kinase inhibition.

02 /Properties

Molecular weight	721.84
Empirical formula	C38H35N5O6S2
Assay	≥95%
Form	powder
Colour	yellow
Solubility	45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble0.93 mg/mLmethanol: soluble10 mg/mLDMSO: soluble12 mg/mLchloroform: soluble20 mg/mL
Storage temperature	−20°C

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

127191-97-3

MDL number

MFCD00083180

PubChem substance

24895961

05 /Additional specifications

Gene Information	human ... P2RX7(5027)

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is KN-62 used for?

KN-62 is primarily used as a selective inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII) in biochemical and cell signalling research, particularly within neuroscience.

What is the CAS number and formula for KN-62?

The CAS number for KN-62 is 127191-97-3, and its empirical formula is C38H35N5O6S2.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies KN-62 with an assay of ≥95%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.

How should KN-62 be handled and stored?

Handling KN-62 requires appropriate personal protective equipment, including eyeshields, gloves, and a type N95 (US) or type P1 (EN143) respirator filter. It should be stored at -20°C.

Is KN-62 a controlled substance?

The provided data does not indicate that KN-62 is a controlled substance. However, users should always verify local regulations.

How is KN-62 packed, shipped, and exported?

KN-62 is carefully packed in appropriate containers for stability and safety during transit. Tech Serve Solutions is experienced in exporting chemicals globally, adhering to all necessary regulations.

How can I request a sample or quote for KN-62?

To request a sample or a quote for KN-62, please contact our sales team through the website or by calling our main office. Please provide your specific requirements.