KW-3902

CAS 136199-02-5C20H28N4O2Biochemicals & Reagents

KW-3902 (CAS: 136199-02-5, C20H28N4O2) is a potent and selective adenosine A1 receptor antagonist, also known as Rolofylline. This research chemical is primarily utilised in scientific investigations focused on P2 nucleotide receptors and purinergic signalling pathways. Its defined properties make it a valuable tool for exploring cellular functions and potential therapeutic targets within cell biology and neuroscience research.

IUPAC: 1,3-dipropyl-8-(3-noradamantyl)xanthine,8-(Hexahydro-2,5-methanopentalen-3a(1H)-yl)-3,7-dihydro-1,3-dipropyl-1H-purine-2,6-dione,MK-7418,Rolofylline
Synonyms: Rolofylline1,3-dipropyl-8-(3-noradamantyl)xanthine8-(Hexahydro-2,5-methanopentalen-3a(1H)-yl)-3,7-dihydro-1,3-dipropyl-1H-purine-2,6-dioneMK-7418

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KW-3902 (C20H28N4O2) — chemical structure, CAS 136199-02-5; Life Science, fine chemical supplied by Tech Serve Solutions

AgonistsBioactive Small MoleculesBiochemicals and ReagentsCell BiologyGPCR ModulatorsGPCR ProteinsModulators and AntibodiesMerck

01 /Applications

Adenosine Receptor Research

KW-3902 serves as a selective antagonist for adenosine A1 receptors, enabling detailed studies into their physiological roles. It is instrumental in dissecting purinergic signalling mechanisms and their impact on cellular processes.

Neuroscience and Cell Signaling

As a tool in cell signaling research, KW-3902 aids in understanding neurotransmission and neuromodulation. Its application extends to investigating the complex pathways involved in cell communication within the nervous system.

Drug Discovery and Development

This compound is employed as a drug candidate in preclinical research, particularly for exploring potential treatments related to conditions influenced by adenosine receptor activity. Its availability supports the investigation of novel therapeutic strategies.

02 /Properties

Empirical formula	C20H28N4O2
Assay	≥98% (HPLC)
Form	solid
Solubility	DMSO: soluble20 mg/mL: soluble
Storage temperature	2-8°C

03 /Safety & handling

Hazard statements

H413May cause long-lasting harmful effects to aquatic life

Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

136199-02-5

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is KW-3902 used for?

KW-3902 is used in scientific research as a selective antagonist for adenosine A1 receptors, aiding investigations into purinergic signaling, cell biology, neuroscience, and potential therapeutic applications.

What is the CAS number and chemical formula for KW-3902?

The CAS number for KW-3902 is 136199-02-5, and its chemical formula is C20H28N4O2.

What grade and purity does Tech Serve Solutions supply for KW-3902?

Tech Serve Solutions supplies KW-3902 with a purity of ≥98% (HPLC). This is a research-grade chemical and is not represented as USP, BP, EP, or any other pharmacopoeia grade.

What are the safety considerations for handling KW-3902?

KW-3902 is classified with hazard statement H413, indicating it may cause long lasting harmful effects to aquatic life. Appropriate personal protective equipment should be used, and it should be handled in a well-ventilated area, avoiding release into the environment.

How is KW-3902 shipped and exported?

KW-3902 is typically supplied as a solid and stored at 2-8°C. Tech Serve Solutions is a global supplier and exporter of fine chemicals, pharmaceutical intermediates, and laboratory reagents, equipped to handle international shipments.

How can I request a sample or quote for KW-3902?

To request a sample or a quote for KW-3902, please contact our sales department through the website or by phone, providing your specific requirements.