Itraconazole
Itraconazole (CAS: 84625-61-6), a triazole antifungal agent with the molecular formula C35H38Cl2N8O4 and a molecular weight of 705.63 g/mol, inhibits ergosterol synthesis. It is employed in treating various fungal infections, including histoplasmosis, blastomycosis, cryptococcal meningitis, and aspergillosis. Research applications include studying fungal strain efficacy in murine models and investigating its effects on diabetic rat gastric mucosa.
- IUPAC
- Oriconazole,R51211,Sporanox
- Synonyms
- OriconazoleR51211Sporanox
Antifungal Agent
Itraconazole is a triazole antifungal agent that works by inhibiting cytochrome P-450-dependent enzymes crucial for ergosterol synthesis in fungi. It is clinically used for systemic fungal infections such as histoplasmosis, blastomycosis, cryptococcal meningitis, and aspergillosis.
Research in Fungal Infections
This compound is utilised in research settings to evaluate its efficacy against various strains of fungi, for example, in studies involving murine invasive infections with *Candida* species. It aids in understanding the spectrum of activity of antifungal agents.
Investigating Pathological Effects
Itraconazole has been used in preclinical studies to investigate its impact on pathological changes, such as its effects on the forestomach mucosa in alloxan-induced diabetic rat models, contributing to research in metabolic disease and drug interactions.
| Molecular weight | 705.63 |
|---|---|
| Empirical formula | C35H38Cl2N8O4 |
| Assay | ≥98% (TLC) |
| Solubility | chloroform: soluble50 mg/mL, clear, colorless |
| Storage temperature | 2-8°C |
| Application | Itraconazole is a triazole antifungal agent. It is used to inhibit cytochrome P-450-dependent enzymes and ergosterol synthesis. It has been used against histoplasmosis, blastomycosis, cryptococcal meningitis, and aspergillosis. It′s different formulations are used to study Candida strains in murine invasive infections1. It has been used to study proliferative changes of the forestomach mucosa in alloxan-induced diabetic rats2. |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 22-26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Itraconazole primarily used for?
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Itraconazole is primarily used as a triazole antifungal agent to treat systemic fungal infections, including histoplasmosis, blastomycosis, cryptococcal meningitis, and aspergillosis. It is also used in research to study fungal infections and drug effects.
What are the CAS number and molecular formula for Itraconazole?
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The CAS number for Itraconazole is 84625-61-6, and its molecular formula is C35H38Cl2N8O4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Itraconazole with an assay of ≥98% (TLC). This product is intended for laboratory and research use. TSS does not represent this product as USP, BP, or EP grade.
What are the safety precautions when handling Itraconazole?
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Itraconazole is harmful if swallowed and causes skin and eye irritation, and may cause respiratory irritation. When handling, wear a dust mask type N95 (US), eyeshields, face shields, and gloves. Ensure adequate ventilation.
How is Itraconazole stored and shipped?
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Itraconazole should be stored at 2-8°C. Tech Serve Solutions can pack, ship, and export this chemical globally, adhering to all relevant regulations.
How can I request a sample or quote for Itraconazole?
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To request a sample or a quote for Itraconazole, please contact our sales team through the website or by phone, providing your specific requirements.
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