Isopropyldiphenylphosphine

CAS 6372-40-3(C6H5)2PCH(CH3)2Catalysis & Inorganic

Isopropyldiphenylphosphine (CAS 6372-40-3) is an organophosphorus compound with the linear formula (C6H5)2PCH(CH3)2 and a molecular weight of 228.27 g/mol. It serves as a valuable ligand and catalyst in various organic synthesis reactions, particularly in transition metal catalysis. Its applications span cyanation, carbonylation, and cross-coupling methodologies, making it a key reagent for chemists.

IUPAC: NSC 244305

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Isopropyldiphenylphosphine ((C6H5)2PCH(CH3)2) — chemical structure, CAS 6372-40-3; Chemistry, fine chemical supplied by Tech Serve Solutions

Chemical SynthesisPhosphine CompoundsPhosphine Ligands

01 /Applications

Nickel/Lewis Acid-Catalyzed Reactions

Utilised as a catalyst in nickel/Lewis acid-mediated aryl- and alkenylcyanation of unsaturated bonds, as well as in the cyanoesterification and cyanocarbamoylation of alkynes.

Palladium-Catalyzed Transformations

Functions as a ligand in palladium-catalyzed methoxycarbonylation reactions and decarboxylative cross-coupling processes. It is also employed in the hydroesterification of vinylarenes.

Asymmetric Hydrogenation

A component in iridium complexes for the asymmetric hydrogenation of quinolines, utilising BINOL-derived diphosphonites.

Heck Coupling Reactions

Acts as a ligand precatalyst enabling Heck coupling reactions to proceed effectively at room temperature.

02 /Properties

Molecular weight	228.27
Linear formula	(C6H5)2PCH(CH3)2
Assay	97%
Boiling point	165 °C/11 mmHg(lit.)
Application	Catalyst in:• Nickel/Lewis acid-catalyzed aryl- and alkenylcyanation of unsaturated bonds1• Nickel/Lewis Acid-Catalyzed Cyanoesterification and Cyanocarbamoylation of Alkynes2• Methoxycarbonylation reactions (palladium complex)3• Decarboxylative cross-coupling in the presence of palladium4• Asymmetric hydrogenation of quinolines catalyzed by iridium complexes of BINOL-derived diphosphonites5• Hydroesterification of vinylarenes in complex with palladium6• Ligand precatalyst for room-temperature Heck coupling reactions7
Melting point	40-43 °C(lit.)

03 /Safety & handling

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust, fume, gas or vapours
P305IF IN EYES

Protective equipment	dust mask type N95 (US), Eyeshields, Gloves
Flash point	113 °C / 235.4 °F
Water hazard class (WGK, DE)	3
Hazard codes (EU)	Xi
Risk statements (R)	36/37/38
Safety statements (S)	26-37/39

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

6372-40-3

MDL number

MFCD00015028

PubChem substance

24860440

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Isopropyldiphenylphosphine used for?

Isopropyldiphenylphosphine is used as a catalyst and ligand in various organic synthesis reactions, including cyanation, carbonylation, and cross-coupling methodologies, particularly in transition metal catalysis.

What is the CAS number and formula for Isopropyldiphenylphosphine?

The CAS number for Isopropyldiphenylphosphine is 6372-40-3 and its linear formula is (C6H5)2PCH(CH3)2.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Isopropyldiphenylphosphine with a purity of 97%. We do not represent this product as USP, BP, or EP grade.

How should Isopropyldiphenylphosphine be handled?

Isopropyldiphenylphosphine is classified as a Warning substance, with hazards including skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Appropriate personal protective equipment, including a dust mask (N95), eyeshields, and gloves, should be used. Ensure adequate ventilation.

How is Isopropyldiphenylphosphine packed and shipped?

Isopropyldiphenylphosphine is carefully packed and exported globally by Tech Serve Solutions, adhering to all relevant shipping regulations for chemical compounds.

How can I request a quote or sample for Isopropyldiphenylphosphine?

To request a quote or sample for Isopropyldiphenylphosphine, please contact the Tech Serve Solutions sales department through our website or by phone.