Isobutyryl chloride
Isobutyryl chloride (CAS: 79-30-1) is a clear liquid with the linear formula (CH3)2CHCOCl and a molecular weight of 106.55 g/mol. This acylating agent is valuable in organic synthesis, particularly for introducing the isobutyryl group. It finds application in the preparation of polymers and the derivatization of various organic compounds, including amines, nucleosides, and pyrroles. Its utility extends to the identification and separation of complex natural products.
Polymer Synthesis
Isobutyryl chloride has been utilised in the synthesis of polyethylenimines, specifically those terminated with isobutyramide groups, contributing to the development of novel polymeric materials.
Organic Synthesis Reagent
This compound serves as a versatile acylating agent for various organic substrates. It is employed in the derivatization of ketimine derivatives of α-amino esters, nucleosides, and pyrroles, enabling further structural modifications.
Natural Product Analysis
Isobutyryl chloride has been used in analytical procedures for the separation and identification of compounds such as shikonin and its ester derivatives, aiding in the characterisation of plant metabolites.
| Molecular weight | 106.55 |
|---|---|
| Linear formula | (CH3)2CHCOCl |
| Assay | 98% |
| Boiling point | 91-93 °C(lit.) |
| Density | 1.017 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.407(lit.) |
| Vapour pressure | 0.07 mmHg (20 °C) |
| Melting point | −90 °C(lit.) |
| Application | Isobutyryl chloride was used in the synthesis of fully isobutyramide terminated hyperbranched polyethylenimines. It was used in the separation and identification of shikonin and its ester derivatives in the root epidermis of Echium italicum L. It was employed as versatile acylating agent for the ketimine derivatives of α-amino esters1, nucleosides2 and pyrroles3. |
Hazard statements
- H225Highly flammable liquid and vapour
- H314Causes severe skin burns and eye damage
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 8 °C / 46.4 °F |
| Transport (UN / ADR) | UN 2395 8(3) / PGII |
| Water hazard class (WGK, DE) | 1 |
| Hazard codes (EU) | F,C |
| Risk statements (R) | 11-35 |
| Safety statements (S) | 16-23-26-36-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Isobutyryl chloride used for?
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Isobutyryl chloride is used as an acylating agent in organic synthesis for preparing polymers and derivatizing compounds like amines, nucleosides, and pyrroles. It also aids in the separation and identification of natural products.
What is the CAS number and formula for Isobutyryl chloride?
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The CAS number for Isobutyryl chloride is 79-30-1, and its linear formula is (CH3)2CHCOCl.
What grade and purity does Tech Serve Solutions supply for Isobutyryl chloride?
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Tech Serve Solutions supplies Isobutyryl chloride with a minimum assay of 98%. This product is intended for laboratory and research use; TSS does not represent it as USP, BP, or EP grade.
How should Isobutyryl chloride be handled safely?
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Isobutyryl chloride is a dangerous substance, indicated by GHS02 and GHS05 symbols, with the signal word 'Danger'. It is highly flammable (H225) and causes severe skin burns and eye damage (H314). Handle with extreme caution, using appropriate personal protective equipment including a faceshield, chemical-resistant gloves, and eye protection in a well-ventilated area. Refer to the Safety Data Sheet for comprehensive handling guidelines.
Is Isobutyryl chloride a controlled substance?
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The provided data does not indicate that Isobutyryl chloride is a controlled substance.
How is Isobutyryl chloride packed, shipped, and exported?
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Isobutyryl chloride is shipped according to international regulations for hazardous materials, designated as UN 2395, Class 8(3), Packing Group II. TSS ensures compliance with all export and shipping requirements for hazardous chemicals.
How can I request a quote or sample for Isobutyryl chloride?
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To request a quote or a sample of Isobutyryl chloride, please contact our sales team through the website or via email, providing your specific requirements and shipping details.
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