Isobutyric anhydride
Isobutyric anhydride (CAS: 97-72-3) is a carboxylic acid anhydride with the linear formula (CH3)2CHCO2COCH(CH3)2 and a molecular weight of 158.19 g/mol. This clear liquid is primarily employed as an organic building block and an acylating agent in chemical synthesis. Its properties make it suitable for various research and industrial applications where the introduction of an isobutyryl group is required, contributing to the development of complex organic molecules.
- IUPAC
- 2-Methylpropionic anhydride
- Synonyms
- 2-Methylpropionic anhydride

Organic Synthesis Intermediate
Isobutyric anhydride serves as a versatile intermediate in organic synthesis. It is used to introduce the isobutyryl group onto alcohols and amines, facilitating the formation of esters and amides, respectively.
Acylating Agent
As a potent acylating agent, this compound is valuable in reactions requiring the addition of the isobutyryl moiety. This is crucial for modifying the structure of organic molecules in multi-step synthetic pathways.
Building Block for Complex Molecules
Its role as a building block is essential in constructing more complex organic structures. Researchers and chemists utilise Isobutyric anhydride in the development of novel compounds with potential applications in various fields.
| Molecular weight | 158.19 |
|---|---|
| Linear formula | (CH3)2CHCO2COCH(CH3)2 |
| Assay | 97% |
| Boiling point | 182 °C(lit.) |
| Density | 0.954 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.406(lit.) |
| Vapour pressure | 10 mmHg (67 °C) |
| Melting point | −56 °C(lit.) |
| Vapour density | 5.45 (vs air) |
| Autoignition temp | 624 °F |


Hazard statements
- H301Toxic if swallowed
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 68 °C / 154.4 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 21/22-34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Isobutyric anhydride primarily used for?
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Isobutyric anhydride is primarily used as an organic building block and an acylating agent in chemical synthesis for introducing the isobutyryl group.
What is the CAS number and formula for Isobutyric anhydride?
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The CAS number is 97-72-3 and the linear formula is (CH3)2CHCO2COCH(CH3)2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Isobutyric anhydride with an assay of 97%. This product is typically considered a technical or research grade, and TSS does not represent it as USP, BP, or EP grade.
How should Isobutyric anhydride be handled safely?
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Isobutyric anhydride is classified as Dangerous. It is corrosive and toxic if swallowed or in contact with skin. Handling requires appropriate personal protective equipment, including eyeshields, faceshields, gloves, and suitable respiratory protection. Always refer to the Safety Data Sheet (SDS) for detailed handling and storage information.
How is Isobutyric anhydride packed, shipped, and exported?
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Isobutyric anhydride is carefully packed to ensure safe transit and is available for domestic and international export through Tech Serve Solutions.
How can I request a quote or sample for Isobutyric anhydride?
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To request a quote or sample for Isobutyric anhydride, please contact our sales team through the website or by phone, providing your specific requirements.
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