Iodotrimethylsilane
Iodotrimethylsilane (CAS 16029-98-4), with the molecular formula (CH3)3SiI and a molar mass of 200.09 g/mol, is a highly reactive organosilicon compound. It serves as an efficient reagent for the cleavage of various functional groups including ethers, esters, carbamates, ketals, and lactones. This compound is a valuable tool in organic synthesis, particularly for deprotection strategies in complex molecule construction.
- IUPAC
- TMIS,Trimethyliodosilane
- Synonyms
- TMISTrimethyliodosilane
Ether Cleavage
Iodotrimethylsilane is an effective reagent for the regioselective cleavage of ethers, enabling the deprotection of ether functionalities in complex organic molecules.
Ester and Lactone Saponification
It efficiently cleaves ester and lactone bonds, which is useful for deprotection and hydrolysis reactions in synthetic organic chemistry.
Carbamate and Ketal Deprotection
This reagent is employed for the removal of carbamate and ketal protecting groups, facilitating subsequent synthetic transformations.
Derivatization Reagent
Iodotrimethylsilane can be used as a derivatizing agent in analytical chemistry for the preparation of volatile derivatives suitable for gas chromatography.
| Molecular weight | 200.09 |
|---|---|
| Linear formula | (CH3)3SiI |
| Assay | ≥98.0% (AT) |
| Boiling point | 106 °C(lit.) |
| Density | 1.406 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.471(lit.) |
| Storage temperature | −20°C |
| Contains / stabiliser | ~1% copper as stabilizer |
| Application | Efficient reagent for cleaving ethers, esters, carbamates, ketals, and lactones.1 |
Hazard statements
- H225Highly flammable liquid and vapour
- H314Causes severe skin burns and eye damage
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | -31 °C / -23.8 °F |
| Transport (UN / ADR) | UN 2924 8(3) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,C |
| Risk statements (R) | 11-14-34 |
| Safety statements (S) | 16-26-36/37/39-43-45 |
| Supplemental hazards | Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Iodotrimethylsilane used for?
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Iodotrimethylsilane is primarily used as an efficient reagent for cleaving ethers, esters, carbamates, ketals, and lactones in organic synthesis.
What is the CAS number and formula for Iodotrimethylsilane?
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The CAS number is 16029-98-4 and the linear formula is (CH3)3SiI.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Iodotrimethylsilane with an assay of ≥98.0% (AT). This is a technical/research grade material and is not represented as USP/BP/EP.
How should I handle Iodotrimethylsilane safely?
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Iodotrimethylsilane is highly flammable and corrosive. It reacts violently with water, causing severe skin burns and eye damage. Handle with extreme care in a well-ventilated area, wearing appropriate personal protective equipment including gloves, goggles, and a faceshield. Store under inert atmosphere at -20°C and keep away from ignition sources.
Is Iodotrimethylsilane supplied with a stabilizer?
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Yes, Iodotrimethylsilane is supplied with approximately 1% copper as a stabilizer.
How is Iodotrimethylsilane packed and shipped?
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Iodotrimethylsilane is classified as UN 2924, Hazard Class 8(3), Packing Group II. It is shipped internationally by Tech Serve Solutions, a global supplier and exporter.
How can I request a quote or sample of Iodotrimethylsilane?
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Please contact Tech Serve Solutions directly via our website or sales team to request a quote or a sample of Iodotrimethylsilane.
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