HOE 140

CAS 138614-30-9C59H89N19O13SBiochemicals & Reagents

HOE 140 (CAS 138614-30-9), a peptide with the empirical formula C59H89N19O13S and a molecular weight of 1304.52 g/mol, is a potent bradykinin B2 receptor antagonist. Utilised in biochemical research, it serves as a valuable tool for investigating the kallikrein-kinin system. Its specific action on BDKRB2 receptors makes it instrumental in cell signalling and neuroscience studies, particularly for understanding inflammatory and pain pathways.

IUPAC: D-Arg-L-Arg-L-Pro-L-Hyp-Gly-L-(2-thienyl)Ala-L-Ser-D-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-L-(2α,3β,7aβ)-octahydro-1H-indole-2-carbonyl-L-Arg,Icatibant acetate

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HOE 140 (C59H89N19O13S) — chemical structure, CAS 138614-30-9; Life Science, fine chemical supplied by Tech Serve Solutions

Bioactive Small MoleculesBiochemicals and ReagentsBradykininsCell BiologyGPCR ModulatorsGPCR ProteinsModulators and AntibodiesNeuropeptidesPeptides and ProteinsPeptides for Cell Biology

01 /Applications

Bradykinin Receptor Antagonism

HOE 140 functions as a selective antagonist for the bradykinin B2 receptor (BDKRB2). It is employed in research settings to block the effects of bradykinin, aiding the study of its physiological and pathological roles.

Cell Signalling and Neuroscience Research

This compound is used to investigate cellular signalling pathways involving bradykinin, particularly within the central nervous system. Its application helps elucidate mechanisms related to pain, inflammation, and cardiovascular regulation.

Biochemical and Pharmaceutical Research

As a bioactive small molecule, HOE 140 is a key reagent in biochemical research. It aids in the development and understanding of therapeutic targets related to the kallikrein-kinin system and associated disorders.

02 /Properties

Molecular weight	1304.52
Empirical formula	C59H89N19O13S
Assay	≥94%
Storage temperature	−20°C

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

138614-30-9

MDL number

MFCD00213940

05 /Additional specifications

Gene Information	human ... BDKRB2(624)mouse ... BDKRB2(12062)rat ... BDKRB2(25245)

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is HOE 140 used for?

HOE 140 is primarily used as a bradykinin B2 receptor antagonist in biochemical and cell signalling research, aiding the study of the kallikrein-kinin system, pain, and inflammation pathways.

What are the CAS number and formula for HOE 140?

The CAS number for HOE 140 is 138614-30-9, and its empirical formula is C59H89N19O13S.

What grade and purity does Tech Serve Solutions supply for HOE 140?

Tech Serve Solutions supplies HOE 140 with a purity of ≥94% (assay). This product is intended for research purposes and is not supplied as USP, BP, EP, or pharmacopoeia grade.

What are the safety and handling requirements for HOE 140?

HOE 140 requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. It is classified under WGK Germany 3, indicating a high hazard to water.

How is HOE 140 shipped and exported by TSS?

HOE 140 is typically stored at -20°C. Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, handling international shipments of research compounds.