GW9508
GW9508 (CAS: 885101-89-3, C22H21NO3) is a selective FFA1/GPR40 agonist with a molecular weight of 347.41 g/mol. This compound is utilised in cell biology research to investigate the function of free fatty acid receptors. It plays a role in understanding glucose-stimulated insulin release, type 2 diabetes pathogenesis, bone loss mechanisms, and inflammatory pain responses.
- IUPAC
- 4-(3-Phenoxybenzylamino)phenylpropionic acid
Investigating FFA1/GPR40 Receptor Function
GW9508 serves as a selective agonist for FFA1/GPR40 receptors, enabling researchers to differentiate and characterise these crucial cell surface proteins in various biological processes.
Type 2 Diabetes Research
This compound is employed to study the involvement of FFA1/GPR40 receptors in the enhancement of glucose-stimulated insulin release, a key pathway affected in type 2 diabetes.
Bone Metabolism Studies
GW9508 can be used to explore the protective role of FFA1/GPR40 receptors against ovariectomy-induced bone loss by inhibiting osteoclast differentiation.
Inflammatory Pain Mechanisms
The compound aids in the investigation of how FFA1/GPR40 receptors influence complete Freund's adjuvant (CFA)-induced inflammatory chronic pain, offering insights into pain management.
| Molecular weight | 347.41 |
|---|---|
| Empirical formula | C22H21NO3 |
| Assay | ≥98% (HPLC) |
| Form | white powder |
| Solubility | DMSO: >20 mg/mL |
| Storage temperature | 2-8°C |
| Application | GW9508, a selective FFA1/GPR40 agonist, may be used to differentiate and characterize the free fatty acid receptor FFA1/GPR40. GW9508 is used to study the role of FFA1/GPR40 receptors in processes such as the free fatty acid enhancement of glucose-stimulated insulin release and type 2 diabetes. GW9508 is used to study the process by which FFA1/GPR40 receptors protect from ovariectomy-induced bone loss in vivo though inhibition of osteoclast differentiation and suppress complete Freund′s adjuvant (CFA)-Induced inflammatory chronic pain.1,2 |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H318Causes serious eye damage
- H335May cause respiratory irritation
- H410Very toxic to aquatic life with long-lasting effects
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P273Avoid release to the environment
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P501Dispose of contents and container per local regulations
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Transport (UN / ADR) | UN 3077 9 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn,N |
| Risk statements (R) | 22-37/38-41-50/53 |
| Safety statements (S) | 26-39-60-61 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is GW9508 used for?
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GW9508 is used as a selective FFA1/GPR40 agonist in cell biology research to study its roles in glucose-stimulated insulin release, type 2 diabetes, ovariectomy-induced bone loss, and inflammatory pain.
What are the CAS number and formula for GW9508?
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The CAS number for GW9508 is 885101-89-3, and its empirical formula is C22H21NO3.
What grade and purity does Tech Serve Solutions supply for GW9508?
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Tech Serve Solutions supplies GW9508 with a purity of ≥98% (HPLC). TSS does not represent this product as USP, BP, or EP grade.
How should GW9508 be handled safely?
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GW9508 is classified with GHS hazards including H302, H315, H318, H335, and H410. Handle with appropriate personal protective equipment such as a dust mask (type N95), eyeshields, faceshields, and gloves in a well-ventilated area. Avoid dust formation and release into the environment.
How is GW9508 packed, shipped, and exported?
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GW9508 is supplied as a white powder and is typically stored at 2-8°C. As a global supplier, TSS exports chemicals worldwide, adhering to all relevant shipping regulations, including UN 3077 for transport.
How can I request a quote or sample of GW9508?
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To request a quote or sample of GW9508, please contact our sales team through the website or by phone.
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