Gramine
Gramine (CAS: 87-52-5; C11H14N2) is a naturally occurring alkaloid with a molecular weight of 174.24 g/mol. This versatile indole derivative serves as a key building block in organic synthesis. Its applications span the preparation of pharmaceuticals, including dopamine D2 receptor antagonists and anti-malarial agents, as well as its use in nutrition research and the study of plant biochemistry.
- IUPAC
- 3-(Dimethylaminomethyl)indole,Donaxine,NSC 16892
- Synonyms
- 3-(Dimethylaminomethyl)indoleDonaxineNSC 16892
Pharmaceutical Intermediate
Gramine is utilised as a crucial reactant in the synthesis of various pharmaceutical compounds, such as dopamine D2 receptor antagonists and anti-malarial drugs. It is also employed in the preparation of DL-tryptophan and serotonin 5-HT6 receptor ligand templates.
Chemical Synthesis Reagent
This compound serves as a valuable building block for the creation of complex organic molecules. It is instrumental in the preparation of 5-indolyl-Mannich bases, 3-vinylindoles, and selective protein kinase c delta (PKCδ) down regulators.
Biochemical Research
Gramine finds application in cell biology and nutrition research, notably as a potential detoxification inhibitor of brassinin, a phytoalexin found in cruciferous plants. It is also investigated for its role in inhibiting human mast cell chymase.
| Molecular weight | 174.24 |
|---|---|
| Empirical formula | C11H14N2 |
| Assay | 99% |
| Application | Reactant for preparation of:• Dopamine D2 receptor antagonists1• Anti-malarial drugs2• 5-indolyl-Mannich bases3• Proliferation inhibitors4• Inhibitors of human mast cell chymase5• Preparation of DL-tryptophan6• Potential detoxification inhibitors of the crucifer phytoalexin brassinin7• 3-vinylindoles8• Serotonin 5-HT6 receptor ligand templates9• Selective protein kinase c delta (PKCδ) down regulators10 |
| Melting point | 132-134 °C(lit.) |
| Flash point | 167 °C / 332.6 °F |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Gramine primarily used for?
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Gramine is used as a reactant in the synthesis of various pharmaceutical agents, including dopamine D2 receptor antagonists and anti-malarial drugs, and as a building block in organic chemistry for compounds like 5-indolyl-Mannich bases and 3-vinylindoles. It also has applications in cell biology and nutrition research.
What are the CAS number and molecular formula for Gramine?
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The CAS number for Gramine is 87-52-5, and its molecular formula is C11H14N2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Gramine with an assay of 99%. We do not represent this product as USP, BP, or EP grade.
What are the safety considerations for handling Gramine?
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Gramine is classified with WGK (Germany) rating 3. It is combustible and has a flash point of 167 °C (332.6 °F). Handle with appropriate personal protective equipment in a well-ventilated area.
How is Gramine packed, shipped, and exported?
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Tech Serve Solutions packs, ships, and exports Gramine adhering to all relevant international regulations for chemical handling and transport. Specific details can be provided upon request.
How can I request a quote or sample for Gramine?
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To request a quote or sample of Gramine, please contact our sales team through the website or by phone, providing your details and the quantity required.
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