Fmoc-1-Nal-OH
Fmoc-1-Nal-OH (CAS 96402-49-2), with the molecular formula C28H23NO4 and a molecular weight of 437.49 g/mol, is a protected unnatural amino acid derivative. It is primarily utilised in peptide synthesis and chemical biology research for the incorporation of naphthylalanine residues. This compound serves as a key building block in the creation of modified peptides with specific structural or functional properties, advancing research in chemical synthesis and related fields.
- IUPAC
- Fmoc-3-(1-naphthyl)-L-alanine

Peptide Synthesis
Fmoc-1-Nal-OH is employed as a protected amino acid in solid-phase and solution-phase peptide synthesis. It allows for the introduction of a 1-naphthylalanine residue into peptide sequences, enabling the study of structure-activity relationships and the development of novel peptide-based therapeutics.
Chemical Biology
This unnatural amino acid derivative is valuable in chemical biology for creating peptides with unique spectroscopic or binding properties. The naphthyl group can act as a fluorescent probe or influence the conformational preferences of the peptide.
Chemical Synthesis
As a specialised building block, Fmoc-1-Nal-OH is integral to complex organic synthesis projects. Its defined structure and protecting group facilitate regioselective and stereoselective reactions in the construction of intricate molecular architectures.
Unnatural Amino Acid Research
Researchers utilise Fmoc-1-Nal-OH to explore the impact of unnatural amino acids on protein structure, function, and stability. This contributes to a deeper understanding of protein engineering and the design of novel biomaterials.
| Molecular weight | 437.49 |
|---|---|
| Empirical formula | C28H23NO4 |
| Assay | ≥98.0% |
| Storage temperature | 2-8°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-1-Nal-OH used for?
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Fmoc-1-Nal-OH is primarily used in peptide synthesis and chemical biology research as a building block for incorporating 1-naphthylalanine into peptide sequences. It is also valuable in chemical synthesis and unnatural amino acid research.
What is the CAS number and molecular formula for Fmoc-1-Nal-OH?
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The CAS number for Fmoc-1-Nal-OH is 96402-49-2, and its molecular formula is C28H23NO4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Fmoc-1-Nal-OH with an assay of ≥98.0%. This product is intended for research and laboratory use; TSS does not represent it as USP, BP, or EP grade.
How should Fmoc-1-Nal-OH be handled and stored?
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Handling requires appropriate personal protective equipment, including eyeshields and gloves, and a type N95 (US) or type P1 (EN143) respirator filter. The recommended storage temperature is 2-8°C.
Is Fmoc-1-Nal-OH a controlled substance?
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The provided data does not indicate that Fmoc-1-Nal-OH is a controlled substance.
How is Fmoc-1-Nal-OH packed and shipped?
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Fmoc-1-Nal-OH is carefully packed and can be exported globally by Tech Serve Solutions to meet your research requirements.
How can I request a quote or sample for Fmoc-1-Nal-OH?
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To request a quote or sample, please contact the Tech Serve Solutions sales team through our website or by phone, providing your specific requirements.
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