FK-506 monohydrate

CAS 109581-93-3C44H69NO12 · H2OBiochemicals & Reagents

FK-506 monohydrate (CAS 109581-93-3), with the empirical formula C44H69NO12 · H2O and a molecular weight of 822.03 g/mol, is a bioactive small molecule. It functions as an inhibitor, notably of Calcineurin (Protein Phosphatase 2B). This compound is crucial in cell biology research, particularly in studies of cell signaling and neuroscience. Tech Serve Solutions supplies this high-purity powder for research and development purposes.

IUPAC: Tacrolimus

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FK-506 monohydrate (C44H69NO12 · H2O) — chemical structure, CAS 109581-93-3; Life Science, fine chemical supplied by Tech Serve Solutions

A to CBioactive Small MoleculesBiochemicals and ReagentsCalcineurinCell BiologyEnzyme InhibitorsEnzyme Inhibitors by EnzymeEnzymesInhibitorsand Substrates

01 /Applications

Calcineurin Inhibition

FK-506 monohydrate is a potent inhibitor of Calcineurin (Protein Phosphatase 2B). This property makes it invaluable for studying the role of Calcineurin in various cellular processes, including T-cell activation and immune responses.

Cell Signaling Research

As a key regulator in cell signaling pathways, FK-506 monohydrate is used to investigate the intricate mechanisms governing cell communication and function. Its application is particularly relevant in neuroscience research.

Enzyme Inhibition Studies

This compound serves as a specific inhibitor for serine/threonine phosphatases. Researchers utilise it to elucidate the functions and regulatory mechanisms of these critical enzymes within biological systems.

02 /Properties

Molecular weight	822.03
Empirical formula	C44H69NO12 · H2O
Assay	≥98% (HPLC)
Form	powder
Solubility	DMSO: soluble20 mg/mL
Storage temperature	−20°C

03 /Safety & handling

GHS hazard pictogram: Toxic (GHS06) — Toxic

Danger

Hazard statements

H301Toxic if swallowed

Precautionary statements

P301IF SWALLOWED

Protective equipment	Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Transport (UN / ADR)	UN 2811 6.1 / PGIII
Water hazard class (WGK, DE)	3
Hazard codes (EU)	T
Risk statements (R)	25
Safety statements (S)	45

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

109581-93-3

MDL number

MFCD11045918

PubChem substance

24724482

05 /Additional specifications

Gene Information	human ... FKBP1A(2280)

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is FK-506 monohydrate used for?

FK-506 monohydrate is primarily used as a Calcineurin inhibitor for research in cell biology, immunology, and neuroscience, and for studying cell signaling pathways.

What is the CAS number and formula for FK-506 monohydrate?

The CAS number for FK-506 monohydrate is 109581-93-3, and its empirical formula is C44H69NO12 · H2O.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies FK-506 monohydrate with an assay of ≥98% by HPLC. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.

How should FK-506 monohydrate be handled safely?

FK-506 monohydrate is classified as Danger (GHS06) with hazard statement H301 (Toxic if swallowed). Recommended personal protective equipment includes eyeshields, faceshields, gloves, and P2 respirator cartridges. Handle with extreme care to avoid ingestion and exposure.

How is FK-506 monohydrate packed, shipped, and exported?

FK-506 monohydrate is shipped as a powder under UN 2811, Hazard Class 6.1, Packing Group III. TSS is a specialist global supplier and exporter of fine chemicals.