Etoposide

CAS 33419-42-0C29H32O13Biochemicals & Reagents

Etoposide (CAS 33419-42-0) is a synthetic antineoplastic antibiotic with the molecular formula C29H32O13 and a molecular weight of 588.56 g/mol. It functions as a topoisomerase II inhibitor, playing a critical role in cancer research and therapy. Available as a white powder, Etoposide is primarily utilised for its cytotoxic properties in the development of cancer treatments and related biomedical research.

IUPAC: 4′-Demethylepipodophyllotoxin 9-(4,6-O-ethylidene-β-D-glucopyranoside),VP-16-213
Synonyms: 4′-Demethylepipodophyllotoxin 9-(4,6-O-ethylidene-β-D-glucopyranoside)VP-16-213

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Etoposide (C29H32O13) — chemical structure, CAS 33419-42-0; Life Science, fine chemical supplied by Tech Serve Solutions

AntibioticsAntibiotics A to ZAntibiotics A-FAntibiotics by ApplicationAntitumor AgentsApoptosis and Cell CycleApplication IndexBioactive Small MoleculesBiochemicals and ReagentsCancer Research

01 /Applications

Antineoplastic Agent Research

Etoposide is investigated for its efficacy as an antineoplastic agent, specifically targeting cancer cells by interfering with DNA replication and cell division. Its mechanism involves inhibiting topoisomerase II, crucial for DNA repair and replication processes in rapidly dividing cells.

Apoptosis and Cell Cycle Studies

This compound is employed in research to study apoptosis (programmed cell death) and cell cycle regulation. By inducing DNA strand breaks, Etoposide can trigger cellular signalling pathways leading to cell death, making it a valuable tool for understanding these fundamental biological processes.

Biomedical and Pharmaceutical Development

As a synthetic derivative of podophyllotoxin, Etoposide serves as a vital reagent in preclinical drug discovery and development. Its well-defined pharmacological profile aids in the exploration of new therapeutic strategies against various malignancies.

02 /Properties

Molecular weight	588.56
Empirical formula	C29H32O13
Assay	≥98%
Form	powder
Colour	white
Solubility	DMSO: soluble30 mg/mL
Biological source	synthetic
Melting point	236-251 °C(lit.)

03 /Safety & handling

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

GHS hazard pictogram: Health hazard (GHS08) — Health hazard

Danger

Hazard statements

H302Harmful if swallowed
H350May cause cancer

Precautionary statements

P201Obtain special instructions before use
P308IF exposed or concerned

Protective equipment	Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Water hazard class (WGK, DE)	3
Hazard codes (EU)	T
Risk statements (R)	45-22
Safety statements (S)	53-45

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

33419-42-0

MDL number

MFCD00869325

PubChem substance

24278178

05 /Additional specifications

Pka	9.8
Gene Information	human ... ABCB1(5243), CYP3A4(1576), TOP2A(7153)mouse ... Abcb1a(18671), Abcb1b(18669)rat ... Top2a(360243)

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is Etoposide used for?

Etoposide is used in cancer research and the development of antineoplastic therapies due to its role as a topoisomerase II inhibitor, impacting DNA replication and cell division. It is also utilized in studies concerning apoptosis and cell cycle regulation.

What are the CAS number and formula for Etoposide?

The CAS number for Etoposide is 33419-42-0, and its empirical formula is C29H32O13.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Etoposide with an assay of ≥98%. We do not represent this product as USP, BP, EP, or any other pharmacopoeial grade.

What are the safety and handling requirements for Etoposide?

Etoposide is classified as dangerous with signal word 'Danger' and hazards including H302 (Harmful if swallowed) and H350 (May cause cancer). Appropriate personal protective equipment includes eyeshields, gloves, and N100/P3 respirators. Handle with extreme caution in a controlled environment.

How is Etoposide packaged and shipped?

Etoposide is supplied as a white powder. Specific packaging details for export are available upon request, adhering to international shipping regulations for chemical compounds.