Ethynylmagnesium bromide solution
Ethynylmagnesium bromide solution (CAS: 4301-14-8, HC≡CMgBr, MW: 129.24) is an organometallic reagent supplied by Tech Serve Solutions as a 0.5 M solution in THF. This versatile Grignard reagent is utilised in organic synthesis for the introduction of the ethynyl group. Its reactivity makes it valuable in the preparation of alkynes and for specific alkyne-containing intermediates in more complex synthetic pathways.
Preparation of Alkyne Components
Used in the preparation of the alkyne component in enyne cross-metathesis reactions, facilitating the synthesis of conjugated dienes.
Diastereoselective Ethynylation
Employed in the diastereoselective ethynylation of chiral α-(dibenzylamino) aldehydes, a key step in stereoselective synthesis.
Grignard Reagent Chemistry
As a Grignard reagent, it participates in nucleophilic addition reactions with various electrophiles, enabling the formation of new carbon-carbon bonds.
| Molecular weight | 129.24 |
|---|---|
| Linear formula | HC≡CMgBr |
| Density | 0.94 g/mL at 25 °C |
| Concentration | 0.5 M in THF |
| Storage temperature | 2-8°C |
| Application | Preparation of the alkyne component in an enyne cross-metathesis leading to conjugated dienes.1 Diastereoselective ethynylation of chiral α-(dibenzylamino) aldehydes.2 |
Hazard statements
- H225Highly flammable liquid and vapour
- H261In contact with water releases flammable gas
- H314Causes severe skin burns and eye damage
- H335May cause respiratory irritation
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P231Handle under inert gas
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P422
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | -29 °C / -20.2 °F |
| Transport (UN / ADR) | UN 3399 4.3/PG 2 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,C |
| Risk statements (R) | 11-14/15-19-34-37 |
| Safety statements (S) | 9-16-26-36/37/39-43-45 |
| Supplemental hazards | May form explosive peroxides., Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Ethynylmagnesium bromide solution used for?
+
Ethynylmagnesium bromide solution is used in organic synthesis, particularly for preparing alkyne components in enyne cross-metathesis and for the diastereoselective ethynylation of chiral aldehydes.
What are the CAS number and formula for Ethynylmagnesium bromide solution?
+
The CAS number is 4301-14-8 and the linear formula is HC≡CMgBr.
What grade and purity does Tech Serve Solutions supply for Ethynylmagnesium bromide solution?
+
Tech Serve Solutions supplies Ethynylmagnesium bromide solution at a concentration of 0.5 M in THF. We do not specify pharmacopoeia grades (USP, EP, BP) unless explicitly stated in the product data. This product is intended for research and laboratory use.
What are the primary safety hazards associated with Ethynylmagnesium bromide solution?
+
This product is highly flammable (H225), reacts violently with water (H261, Supplemental Hazard: Reacts violently with water), causes severe skin burns and eye damage (H314), and may cause respiratory irritation (H335). It may also form explosive peroxides. Strict handling under inert atmosphere and appropriate PPE are essential.
How is Ethynylmagnesium bromide solution shipped and exported?
+
Ethynylmagnesium bromide solution is classified under UN 3399 (Category 4.3, Packing Group II) for transport. Tech Serve Solutions adheres to all international regulations for the safe shipping and export of hazardous chemicals.
How can I request a sample or quote for Ethynylmagnesium bromide solution?
+
To request a sample or a quotation, please contact our sales team through the website or by phone, providing the product name, CAS number, and desired quantity.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis