Ethynylmagnesium chloride solution
Ethynylmagnesium chloride solution (CAS 65032-27-1, CH≡CMgCl) is a reactive organometallic reagent supplied as a 0.5 M solution in Tetrahydrofuran (THF). With a molecular weight of 84.79 g/mol, it serves as a valuable building block in organic synthesis, particularly for introducing ethynyl groups into molecules. Its applications span the synthesis of complex organic compounds, pharmaceuticals, and specialty chemicals, making it a staple in research and development laboratories.
Alkynylation Reactions
Ethynylmagnesium chloride solution is a potent nucleophile used to introduce the ethynyl group (–C≡CH) into organic molecules through reactions with electrophiles such as aldehydes, ketones, and esters.
Organic Synthesis Intermediate
It acts as a key intermediate in the construction of carbon-carbon bonds, enabling the synthesis of diverse organic structures including heterocycles and complex natural product analogues.
Pharmaceutical Research
This reagent is employed in the synthesis pathways of potential drug candidates and active pharmaceutical ingredients (APIs) where the incorporation of an alkynyl moiety is required.
Material Science
The ethynyl group can be incorporated into polymers or advanced materials, potentially influencing their electronic or structural properties.
| Molecular weight | 84.79 |
|---|---|
| Linear formula | CH≡CMgCl |
| Density | 0.921 g/mL at 25 °C |
| Concentration | 0.5 M in THF |
| Storage temperature | 2-8°C |
Hazard statements
- H225Highly flammable liquid and vapour
- H261In contact with water releases flammable gas
- H319Causes serious eye irritation
- H335May cause respiratory irritation
- H351Suspected of causing cancer
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P231Handle under inert gas
- P261Avoid breathing dust, fume, gas or vapours
- P281Use personal protective equipment as required
- P305IF IN EYES
- P422
| Flash point | -27 °C / -16.6 °F |
|---|---|
| Transport (UN / ADR) | UN 2924 8(3) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,Xn |
| Risk statements (R) | 11-19-36/37-40 |
| Safety statements (S) | 16-26-36/37 |
| Supplemental hazards | May form explosive peroxides. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Ethynylmagnesium chloride solution used for?
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Ethynylmagnesium chloride solution is primarily used in organic synthesis as a reagent for alkynylation reactions, allowing the introduction of the ethynyl group into various organic molecules, and as an intermediate in the synthesis of pharmaceuticals and complex organic compounds.
What is the CAS number and formula for Ethynylmagnesium chloride solution?
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The CAS number for Ethynylmagnesium chloride solution is 65032-27-1, and its linear formula is CH≡CMgCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Ethynylmagnesium chloride solution at a concentration of 0.5 M in THF. We do not guarantee pharmacopoeia grades (USP, BP, EP) unless explicitly stated in the product specifications.
How should Ethynylmagnesium chloride solution be handled safely?
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Ethynylmagnesium chloride solution is a highly flammable liquid and vapour (H225) and may form explosive peroxides (supplemental hazard). It can react violently with water (H261), causes serious eye irritation (H319), and may cause respiratory irritation (H335) and is suspected of causing cancer (H351). Handle only under an inert atmosphere, away from heat, sparks, and open flames. Ensure adequate ventilation and wear appropriate personal protective equipment.
How is Ethynylmagnesium chloride solution packed and shipped?
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Ethynylmagnesium chloride solution is typically packed in specialised containers suitable for flammable and reactive liquids. It is shipped according to international regulations for hazardous materials, classified under UN 2924.
How can I request a sample or quote for Ethynylmagnesium chloride solution?
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To request a sample or a quote, please contact our sales team through the website or by calling us directly. Please specify the quantity and any particular requirements you may have.
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