Ethyl (S)-2-(trifluoromethylsulfonyloxy)propionate
Ethyl (S)-2-(trifluoromethylsulfonyloxy)propionate (CAS: 84028-88-6), with the chemical formula CH3CH(OSO2CF3)CO2C2H5 and a molecular weight of 250.19 g/mol, is a chiral triflate ester. It serves as a valuable intermediate in organic synthesis, particularly in asymmetric reactions. Its structure makes it suitable for introducing chiral centres and for use in complex molecule construction within chemical research and development.
- IUPAC
- Ethyl O-trifluoromethanesulfonyl-L-lactate,Ethyl L-lactate 2-O-triflate
- Synonyms
- Ethyl O-trifluoromethanesulfonyl-L-lactateEthyl L-lactate 2-O-triflate

Chiral Building Block
Utilised as a stereodefined building block in the synthesis of complex chiral molecules. Its triflate leaving group facilitates various coupling and substitution reactions.
Asymmetric Synthesis
A key reagent in asymmetric synthesis, enabling the creation of enantiomerically enriched compounds crucial for pharmaceuticals and agrochemicals.
Organic Synthesis Intermediate
Serves as a versatile intermediate in multi-step organic synthesis pathways, offering a reactive chiral centre for further chemical transformations.
| Molecular weight | 250.19 |
|---|---|
| Linear formula | CH3CH(OSO2CF3)CO2C2H5 |
| Assay | ≥96% |
| Boiling point | 34 °C/0.005 mmHg(lit.) |
| Density | 1.342 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.374(lit.) |
| Optical activity | [α]20/D −44°, neat |
| Storage temperature | −20°C |
| Contains / stabiliser | ~1% MgO as stabilizer |

Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 79 °C / 174.2 °F |
| Transport (UN / ADR) | UN 3265 8 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Ethyl (S)-2-(trifluoromethylsulfonyloxy)propionate used for?
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Ethyl (S)-2-(trifluoromethylsulfonyloxy)propionate (CAS: 84028-88-6) is primarily used as a chiral building block and intermediate in asymmetric organic synthesis.
What are the CAS number and chemical formula for this product?
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The CAS number is 84028-88-6 and the chemical formula is CH3CH(OSO2CF3)CO2C2H5.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Ethyl (S)-2-(trifluoromethylsulfonyloxy)propionate with an assay of ≥96%. This product is not supplied as USP, BP, EP, or any pharmacopoeia grade.
What are the safety considerations for handling this chemical?
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This compound is classified with GHS symbol GHS05 and signal word Danger, indicated by hazard statement H314 (Causes severe skin burns and eye damage). Appropriate personal protective equipment, including full-face respirators, gloves, and goggles, must be worn. Handle only in well-ventilated areas and follow all safety precautions.
How is this chemical shipped and exported?
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Ethyl (S)-2-(trifluoromethylsulfonyloxy)propionate is shipped according to UN 3265, Class 8, Packing Group III regulations. Tech Serve Solutions is an experienced global supplier and exporter of fine chemicals.
How can I request a sample or quote?
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To request a sample or obtain a quotation, please contact our sales team through the website or by phone, referencing product CAS 84028-88-6.
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