Ethyl p-toluenesulfonate
Ethyl p-toluenesulfonate (CAS: 80-40-0; Formula: CH3C6H4SO3C2H5; MW: 200.25) is a chemical compound utilised in organic synthesis. As a tosylate ester, it serves as an ethylating agent in various chemical reactions. Its applications are primarily found in research and development settings, particularly in analytical method development for detecting alkylating agents in pharmaceutical synthesis and in extraction techniques for sulfonic acid esters.
Analytical Method Development
Ethyl p-toluenesulfonate has been used in studies to develop and validate rapid, accurate methods for determining residues of common alkylating agents employed in drug synthesis through techniques like in situ derivatization–headspace–gas chromatography–mass spectrometry.
Extraction Method Development
The compound has been utilised in the development of extraction methodologies for methyl and ethyl esters of various sulfonic acids found in active pharmaceutical ingredients, employing solid-phase microextraction coupled with GC/MS.
Organic Synthesis Intermediate
As a tosylate, it functions as an ethylating agent in organic synthesis, facilitating the introduction of ethyl groups in the preparation of more complex molecules.
| Molecular weight | 200.25 |
|---|---|
| Linear formula | CH3C6H4SO3C2H5 |
| Assay | ≥99.0% (GC) |
| Boiling point | 158-162 °C/10 mmHg(lit.) |
| Density | 1.174 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.511(lit.) |
| Application | Ethyl p-toluenesulfonate was used in a study to develop a fast and accurate method for determination of residues of some common alkylating agents employed in drug synthesis by in situ derivatization–headspace–gas chromatography–mass spectrometry1. Ethyl p-toluenesulfonate was used to develop an extraction method for methyl and ethyl esters of various sulfonic acids in active pharmaceutical ingredients using solid-phase microextraction coupled to GC/MS in the selected ion monitoring mode2. |
| Melting point | 29-33 °C(lit.)29-33 °C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Flash point | 158 °C / 316.4 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Ethyl p-toluenesulfonate used for?
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Ethyl p-toluenesulfonate is primarily used in analytical method development for detecting alkylating agents and in extraction techniques for sulfonic acid esters. It also serves as an ethylating agent in organic synthesis.
What is the CAS number and chemical formula for Ethyl p-toluenesulfonate?
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The CAS number for Ethyl p-toluenesulfonate is 80-40-0, and its chemical formula is CH3C6H4SO3C2H5.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Ethyl p-toluenesulfonate with an assay of ≥99.0% (GC). This is a technical grade suitable for research and synthesis; it is not represented as USP/BP/EP.
What are the safety and handling precautions for Ethyl p-toluenesulfonate?
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Ethyl p-toluenesulfonate is a Warning chemical (GHS07) that causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Handle with appropriate personal protective equipment, including a dust mask type N95 (US), eyeshields, and gloves. Ensure adequate ventilation.
How is Ethyl p-toluenesulfonate shipped and exported?
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Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals. We adhere to all relevant shipping regulations for the safe and compliant transport of chemical products worldwide.
How can I request a quote or sample of Ethyl p-toluenesulfonate?
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To request a quote or sample, please contact our sales department via the website or direct email, providing your contact details and the product of interest.
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