[1,2-Bis(diphenylphosphino)ethane]dichlorocobalt(II)
[1,2-Bis(diphenylphosphino)ethane]dichlorocobalt(II), CAS 18498-01-6, is a coordination complex with the molecular formula [(C6H5)2PCH2CH2P(C6H5)2]CoCl2 and a molecular weight of 528.26. This cobalt(II) compound, often abbreviated as dppeeCoCl2, serves as a valuable catalyst in various organic synthesis applications. Its primary utility lies in facilitating specific coupling reactions and addition processes, making it a key reagent in synthetic chemistry laboratories.
- IUPAC
- Dichloro[ethylenebis[diphenylphosphine]]cobalt
- Synonyms
- Dichloro[ethylenebis[diphenylphosphine]]cobalt
![[1,2-Bis(diphenylphosphino)ethane]dichlorocobalt(II) ([(C6H5)2PCH2CH2P(C6H5)2]CoCl2) — chemical structure, CAS 18498-01-6; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F18498-01-6.png&w=3840&q=75)
Intermolecular Enyne Coupling
This cobalt complex is employed as a catalyst to promote regioselective and stereoselective intermolecular enyne coupling reactions. These reactions are crucial for constructing complex molecular architectures.
Cross-Coupling of Alkyl Halides
It facilitates cross-coupling reactions between alkyl halides and aryl Grignard reagents. This application is vital for forming new carbon-carbon bonds efficiently.
Hydrovinylation Reactions
The compound acts as a catalyst in the hydrovinylation of styrene, a process that adds a vinyl group to styrene. This is important for producing specific vinylated aromatic compounds.
Tandem Reactions
It is utilized in tandem radical cyclization and cross-coupling sequences, enabling multiple bond-forming events in a single synthetic operation.
Dimethylation and Hydrodechlorination
The catalyst is effective in promoting dimethylation reactions and hydrodechlorination processes, contributing to functional group transformations.
| Molecular weight | 528.26 |
|---|---|
| Linear formula | [(C6H5)2PCH2CH2P(C6H5)2]CoCl2 |
| Application | Catalyst for:• Regio- and stereoselective intermolecular enyne coupling1• Cross-coupling reactions of alkyl halides with aryl Grignard reagents2• Hydrovinylation of styrene3• Tandem radical cyclization and cross-coupling4• Dimethylation and hydrodechlorination5• Addition reactions6 |
| Melting point | 260 °C (dec.)(lit.) |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 26-37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is [1,2-Bis(diphenylphosphino)ethane]dichlorocobalt(II) used for?
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[1,2-Bis(diphenylphosphino)ethane]dichlorocobalt(II) is primarily used as a catalyst in various organic synthesis reactions, including regio- and stereoselective intermolecular enyne coupling, cross-coupling reactions of alkyl halides with aryl Grignard reagents, hydrovinylation of styrene, and tandem radical cyclization/cross-coupling reactions.
What is the CAS number and formula for this compound?
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The CAS number is 18498-01-6, and its linear formula is [(C6H5)2PCH2CH2P(C6H5)2]CoCl2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound for research and chemical synthesis purposes. The specific assay and purity information is available on the product's Certificate of Analysis. We do not represent this product as meeting USP, BP, EP, or other pharmacopoeia standards.
What are the main safety hazards associated with this chemical?
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This compound is classified as harmful if swallowed, in contact with skin, or if inhaled. It also causes skin irritation, serious eye irritation, and may cause respiratory irritation. Always handle with appropriate personal protective equipment, including a dust mask, eyeshields, and gloves, in a well-ventilated area.
How is this product packed, shipped, and exported?
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This chemical is carefully packed to ensure its integrity during transit. Tech Serve Solutions is experienced in global export regulations for fine chemicals and can facilitate international shipments.
How can I request a sample or quote for this product?
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To request a sample or a quotation, please contact our sales team through the website or by phone. Provide the product name and CAS number (18498-01-6) for prompt service.
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