Ethyl 5-methylindole-2-carboxylate
Ethyl 5-methylindole-2-carboxylate (CAS: 16382-15-3; Formula: C12H13NO2; Molar Mass: 203.24) is a vital heterocyclic building block. This indole derivative serves as a key reactant in sophisticated organic synthesis, enabling the creation of complex molecules. Its applications span the development of novel pharmaceutical agents, including potential anti-inflammatory drugs and cannabinoid receptor antagonists. It is also utilised in cascade reactions for forming fused ring systems.
- IUPAC
- 5-Methylindole-2-carboxylic acid ethyl ester,NSC 30928
Synthesis of Oxazino[4,3-a]indoles
Serves as a reactant in cascade addition-cyclization reactions to produce oxazino[4,3-a]indole derivatives, which are important fused heterocyclic systems.
Preparation of Cannabinoid CB1 Receptor Antagonists
Utilised in the synthesis of indolecarboxamides, a class of compounds investigated for their potential as cannabinoid CB1 receptor antagonists.
Development of Anti-inflammatory Agents
Acts as a precursor for the preparation of indole-3-propionic acids, which have demonstrated anti-inflammatory and analgesic properties.
Friedel-Crafts Acylation Reactions
Engaged as a reactant in Friedel-Crafts acylation with reagents such as nitrobenzoyl chloride, facilitating the introduction of functional groups onto the indole core.
Oximation Reactions
Participates in oximation reactions, offering a route to introduce oxime functionalities into organic molecules.
| Molecular weight | 203.24 |
|---|---|
| Empirical formula | C12H13NO2 |
| Assay | 97% |
| Application | • Reactant for synthesis of oxazino[4,3-a]indoles via cascade addition-cyclization reactions1• Reactant for preparation of indolecarboxamides as cannabinoid CB1 receptor antagonists2• Reactant for preparation of indole-3-propionic acids as antiinflammatory and analgesic agents3• Reactant for Friedel-Crafts acylation with nitrobenzoyl chloride4• Reactant for oximation reactions5 |
| Melting point | 160-164 °C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Ethyl 5-methylindole-2-carboxylate used for?
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Ethyl 5-methylindole-2-carboxylate is used as a reactant in organic synthesis for preparing various compounds, including oxazino[4,3-a]indoles, indolecarboxamides with potential as cannabinoid CB1 receptor antagonists, and indole-3-propionic acids with anti-inflammatory and analgesic properties. It is also involved in Friedel-Crafts acylation and oximation reactions.
What are the CAS number and molecular formula?
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The CAS number is 16382-15-3, and the molecular formula is C12H13NO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Ethyl 5-methylindole-2-carboxylate with a purity of 97%. This is a technical/research grade material, and TSS does not represent it as USP, BP, EP, or any other pharmacopoeia grade.
What are the safety considerations when handling this chemical?
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When handling Ethyl 5-methylindole-2-carboxylate, it is essential to wear eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter should be used. This compound is classified as WGK 3 in Germany, indicating a high hazard level.
How is this product packed, shipped, and exported?
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Tech Serve Solutions packs and ships this chemical product with appropriate measures to ensure safe transit. As a global supplier, we handle export procedures for international customers.
How can I request a sample or a quote?
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To request a sample or a quote for Ethyl 5-methylindole-2-carboxylate, please contact the Tech Serve Solutions sales team through our website or by phone.
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