Ethyl 4-chloroacetoacetate
Ethyl 4-chloroacetoacetate (CAS 638-07-3) is an organic compound with the linear formula ClCH2COCH2CO2C2H5 and a molecular weight of 164.59 g/mol. This versatile chemical building block, primarily used in organic synthesis, features a reactive alpha-chloro ketone and ester functionality. It is a valuable intermediate for the preparation of various complex organic molecules and heterocyclic compounds. Its applications span diverse areas of chemical research and development.
Synthesis of Phosphorus Ylides
Ethyl 4-chloroacetoacetate serves as a key reagent in the synthesis of phosphorus ylides. This application is crucial for Wittig reactions and related olefination processes in organic chemistry.
Organic Building Block
As a functionalised ester and ketone, it is widely employed as a versatile building block in complex organic synthesis. Its reactivity allows for the construction of diverse molecular scaffolds.
Intermediate in Heterocyclic Chemistry
The compound's structure makes it suitable for cyclisation reactions, leading to the formation of various heterocyclic systems relevant in medicinal chemistry and materials science.
| Molecular weight | 164.59 |
|---|---|
| Linear formula | ClCH2COCH2CO2C2H5 |
| Assay | 95% |
| Boiling point | 115 °C/14 mmHg(lit.) |
| Density | 1.218 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.452(lit.) |
| Application | Ethyl 4-chloroacetoacetate was used in the synthesis of phosphorus ylides1. |
Hazard statements
- H301Toxic if swallowed
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 105 °C / 221 °F |
| Transport (UN / ADR) | UN 2922 8/PG 2 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 25-34 |
| Safety statements (S) | 26-36-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Ethyl 4-chloroacetoacetate used for?
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Ethyl 4-chloroacetoacetate is primarily used as a building block in organic synthesis, including the preparation of phosphorus ylides and heterocyclic compounds.
What is the CAS number and formula for Ethyl 4-chloroacetoacetate?
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The CAS number for Ethyl 4-chloroacetoacetate is 638-07-3, and its linear formula is ClCH2COCH2CO2C2H5.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Ethyl 4-chloroacetoacetate with an assay of 95%. This product is suitable for research and technical applications and is not represented as USP, BP, or EP grade.
What are the safety considerations for handling Ethyl 4-chloroacetoacetate?
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Ethyl 4-chloroacetoacetate is classified as corrosive and toxic if swallowed (H301, H314). Handle with extreme care, using appropriate personal protective equipment including full-face respirators, gloves, and goggles. Ensure adequate ventilation.
How is Ethyl 4-chloroacetoacetate packed, shipped, and exported?
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Ethyl 4-chloroacetoacetate is shipped in compliance with international regulations for hazardous materials. Specific packaging details are available upon request. TSS is an experienced global exporter.
How can I request a quote or sample?
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To request a quote or a sample of Ethyl 4-chloroacetoacetate, please contact our sales department through the website or by calling us directly.
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