Ethyl 1-methyl-3-piperidinecarboxylate
Ethyl 1-methyl-3-piperidinecarboxylate (CAS: 5166-67-6; Formula: C9H17NO2; Molar Mass: 171.24) is a heterocyclic building block with a purity of 96%. This compound serves as a key reactant in various organic synthesis applications, including N-demethylation of tertiary amines, reverse Cope elimination reactions, and regioselective oxidation. Its utility extends to the synthesis of chelating agents and in sequential Michael-Michael-Dieckmann cyclizations, making it a valuable intermediate for complex molecule construction.
- IUPAC
- 1-Methyl-nipecotic acid ethyl ester,Ethyl 1-methylnipecotate,NSC 64739
- Synonyms
- 1-Methyl-nipecotic acid ethyl esterEthyl 1-methylnipecotateNSC 64739
N-Demethylation of Tertiary Amines
This compound is utilised as a reactant for the N-demethylation of tertiary amines, a crucial step in modifying amine functionalities in organic synthesis.
Reverse Cope Elimination Reactions
It serves as a reactant in reverse Cope elimination reactions, contributing to the formation of specific chemical structures through controlled elimination pathways.
Regioselective Oxidation
Ethyl 1-methyl-3-piperidinecarboxylate is employed in regioselective oxidation processes, enabling targeted oxidation at specific positions within a molecule.
Synthesis of Chelating Agents
The compound finds application in the synthesis of chelating agents, which are important for metal ion binding in various chemical and biological systems.
Sequential Cyclizations
It is used in sequential Michael-Michael-Dieckmann cyclizations, a complex synthetic strategy for constructing polycyclic heterocyclic systems.
| Molecular weight | 171.24 |
|---|---|
| Empirical formula | C9H17NO2 |
| Assay | 96% |
| Boiling point | 88-89 °C/11 mmHg(lit.) |
| Density | 0.954 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.451(lit.) |
| Application | Reactant for: N-demethylation of tertiary amines1 Reverse cope elimination reactions2 Regioselective oxidation3 Synthesis of chelating agents4 Sequential Michael-Michael-Dieckmann cyclizations5 |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 68 °C / 154.4 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Ethyl 1-methyl-3-piperidinecarboxylate used for?
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Ethyl 1-methyl-3-piperidinecarboxylate is used as a reactant for N-demethylation of tertiary amines, reverse Cope elimination reactions, regioselective oxidation, synthesis of chelating agents, and sequential Michael-Michael-Dieckmann cyclizations.
What are the CAS number and formula for Ethyl 1-methyl-3-piperidinecarboxylate?
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The CAS number is 5166-67-6, and the formula is C9H17NO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Ethyl 1-methyl-3-piperidinecarboxylate with an assay of 96%. We do not represent this product as USP, BP, EP, or any pharmacopoeia grade.
How should Ethyl 1-methyl-3-piperidinecarboxylate be handled safely?
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Handle with appropriate personal protective equipment, including eyeshields and gloves. Ensure adequate ventilation and use a suitable respirator. It is a warning substance that causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335).
Is Ethyl 1-methyl-3-piperidinecarboxylate a controlled substance?
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Based on the provided data, there is no indication that Ethyl 1-methyl-3-piperidinecarboxylate is a controlled substance.
How is this chemical packed, shipped, and exported?
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This chemical is carefully packed to ensure safe transit and is available for global export by Tech Serve Solutions, a specialist supplier since 1998.
How can I request a sample or quote for Ethyl 1-methyl-3-piperidinecarboxylate?
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Please contact Tech Serve Solutions directly via our website or sales channels to request a sample or a quote for Ethyl 1-methyl-3-piperidinecarboxylate.
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