α-Estradiol
α-Estradiol (CAS: 57-91-0), a steroid hormone with the molecular formula C18H24O2 and a molecular weight of 272.38 g/mol, is a key compound in biological research. Primarily known as an estrogen, it plays a vital role in various physiological processes. This white to slight yellow-cast powder is essential for studies investigating cellular signaling, hormone function, and related biological pathways, offering researchers a reliable reagent for in-depth scientific inquiry.
- IUPAC
- 1,3,5(10)-Estratriene-3,17α-diol,3,17α-Dihydroxy-1,3,5(10)-estratriene,Epiestradiol
- Synonyms
- 1,3,5(10)-Estratriene-3,17α-diol3,17α-Dihydroxy-1,3,5(10)-estratrieneEpiestradiol

Endocrinology Research
Investigate the complex mechanisms of hormone action and endocrine system regulation. α-Estradiol serves as a crucial tool for understanding the physiological effects of estrogens in experimental models.
Cell Biology Studies
Explore cellular responses to hormonal stimuli and signalling pathways. Its role as an estrogen allows for detailed examination of cell growth, differentiation, and other vital cellular processes.
Neuroscience Investigations
Examine the influence of steroid hormones on neuronal function and behaviour. This compound can be used in studies exploring the neurobiological effects of estrogenic signalling.
Biochemical Assays
Utilise α-Estradiol as a standard or substrate in biochemical assays related to steroid metabolism and receptor binding. Its defined purity makes it suitable for quantitative analyses.
| Molecular weight | 272.38 |
|---|---|
| Empirical formula | C18H24O2 |
| Assay | ≥98% (TLC) |
| Form | powder |
| Colour | white with slight yellow cast |
| Solubility | ethanol: soluble50 mg/mL, clear, colorless |

Hazard statements
- H351Suspected of causing cancer
Precautionary statements
- P281Use personal protective equipment as required
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 40-48 |
| Safety statements (S) | 22-24/25 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... ESR1(2099), ESR2(2100)rat ... Ar(24208) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is α-Estradiol used for?
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α-Estradiol is used in research settings for studies in endocrinology, cell biology, neuroscience, and biochemical assays, particularly those investigating estrogenic effects and steroid hormone functions.
What are the CAS number and formula for α-Estradiol?
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The CAS number for α-Estradiol is 57-91-0, and its molecular formula is C18H24O2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies α-Estradiol with an assay of ≥98% (TLC). TSS does not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should α-Estradiol be handled safely?
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Handle α-Estradiol with appropriate personal protective equipment, including a dust mask type N95 (US), eyeshields, and gloves, due to the potential hazard H351 (Suspected of causing cancer). Avoid dust formation and inhalation.
Is α-Estradiol a controlled substance?
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The provided safety data does not indicate that α-Estradiol is a controlled substance. However, regulations can vary by jurisdiction.
How is α-Estradiol shipped and exported?
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Tech Serve Solutions, established in 1998, is a specialist global supplier and exporter of fine chemicals and laboratory reagents. We ensure compliant packaging and shipping for international export.
How can I request a quote or sample for α-Estradiol?
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Please contact our sales department through the website or by phone to request a quote or a sample of α-Estradiol. Our team will assist with your specific requirements.
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