DL-Dithiothreitol
DL-Dithiothreitol (CAS 3483-12-3), molecular formula HSCH2CH(OH)CH(OH)CH2SH, is a high-purity chemical supplied by Tech Serve Solutions for chemical synthesis applications, to pharmacopoeia specification (USP, BP, EP). Every batch is tested and ships with a Certificate of Analysis; MSDS and technical data sheets are available on request. Tech Serve Solutions has supplied laboratory reagents, fine chemicals and pharmaceutical intermediates worldwide since 1998.
- IUPAC
- threo-1,4-Dimercapto-2,3-butanediol,Cleland’s reagent,DTT
| Molecular weight | 154.25 |
|---|---|
| Linear formula | HSCH2CH(OH)CH(OH)CH2SH |
| Assay | ≥99.0% (RT) |
| Grade | for molecular biology |
| Density | 1.04 g/mL at 20 °C1.035 g/mL at 25 °C |
| Solubility | H2O: soluble50 mg/mL, clear, colorlessH2O: freely solubleacetone: freely solublechloroform: freely solublediethyl ether: freely solubleethanol: freely solubleethyl acetate: freely soluble |
| pH | 4.0-6.5 (25 °C, 0.1 M in H2O) |
| Melting point | 41-44 °C(lit.)42-43 °C |
| Concentration | 1 M in H2O |
| Storage temperature | 2-8°C |
| Impurities tested | ≤0.3% 4,5-dihydroxy-1,2-dithiane |
| Application | An excellent reagent for maintaining SH groups in reduced state; quantitatively reduces disulfides. DTT is effective in sample buffers for reducing protein disulfide bonds prior to SDS-PAGE. DTT can also be used for reducing the disulfide bridge of the cross-linker N,N′-bis(acryloyl)cystamine to break apart the matrix of a polyacrylamide gel. DTT is less pungent and is less toxic than 2-mercaptoethanol. Typically, a seven fold lower concentration of DTT (100 mM) is needed than is used for 2-mercaptoethanol (5% v/v, 700 mM). |
| Suitability | in accordance for filter test |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Transport (UN / ADR) | UN 3335 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38 |
| Safety statements (S) | 26-36 |
| Cation traces | Ca: ≤10 mg/kgCd: ≤5 mg/kgCo: ≤5 mg/kgCr: ≤5 mg/kgCu: ≤5 mg/kgFe: ≤5 mg/kgK: ≤50 mg/kgMg: ≤5 mg/kgMn: ≤5 mg/kgNa: ≤200 mg/kgNi: ≤5 mg/kgPb: ≤5 mg/kgZn: ≤5 mg/kg |
| Anion traces | sulfate (SO42-): ≤50 mg/kg |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Quality Level | PREMIUM |
|---|---|
| Foreign Activity | DNase, RNase, protease, none detected |
| Uv Absorption | λ: 260 nm Amax: 0.400λ: 280 nm Amax: 0.100 |
| Absorption | absorption/320 nm cut-off |
Documentation
Supplied to USP, BP and EP standards. Every batch ships with a Certificate of Analysis (assay, identity, purity); MSDS and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is DL-Dithiothreitol?
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DL-Dithiothreitol (CAS 3483-12-3), molecular formula HSCH2CH(OH)CH(OH)CH2SH, is a high-purity chemical supplied by Tech Serve Solutions for chemical synthesis applications, to USP, BP and EP standards.
What grades of DL-Dithiothreitol does Tech Serve Solutions supply?
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Tech Serve Solutions supplies DL-Dithiothreitol in USP, BP, EP and reagent/AR grades. Custom specifications for nutraceutical or specialty pharmaceutical applications are available — contact our technical sales team.
What is the CAS number and molecular formula of DL-Dithiothreitol?
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DL-Dithiothreitol has CAS number 3483-12-3 and molecular formula HSCH2CH(OH)CH(OH)CH2SH. Full specifications appear in the table above and in the Certificate of Analysis.
What is the typical minimum order quantity and lead time for DL-Dithiothreitol?
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Sample quantities are available for technical evaluation; bulk MOQ depends on grade and packaging. In-stock material typically ships in 7–10 working days; custom-spec orders take 3–4 weeks. Tech Serve Solutions ships worldwide with full export documentation.
Do you provide a Certificate of Analysis (CoA) with each shipment?
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Yes. Every batch of DL-Dithiothreitol ships with a Certificate of Analysis covering assay, identity and purity tests, plus pharmacopoeia conformance where applicable. MSDS and TDS documents are available on request before order placement.
How should DL-Dithiothreitol be stored?
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Store DL-Dithiothreitol in its original sealed container in a cool, dry place away from direct sunlight and incompatible materials, in line with the storage guidance on the Safety Data Sheet. Reseal between dispensings.
What is DL-Dithiothreitol used for?
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DL-Dithiothreitol is used in chemical synthesis applications across pharmaceutical, research and industrial settings. Our technical team can advise on suitability for your specific process.
How do I request a quote for DL-Dithiothreitol?
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Request a quote with your required grade, quantity and destination via https://www.techservesolutions.in/contact or email info@techservesolutions.in. We respond with specifications, a Certificate of Analysis and pricing.
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