α,α-Diphenyl-N-methyl-L-prolinol
α,α-Diphenyl-N-methyl-L-prolinol (CAS 110529-22-1) is a chemical compound with the molecular formula C18H21NO and a molecular weight of 267.37 g/mol. This proline-based organocatalyst is primarily utilised in asymmetric synthesis and chemical research. It serves as a valuable chiral ligand and reagent in various stereoselective transformations, contributing to the development of enantiomerically pure compounds.
- IUPAC
- (S)-α,α-Diphenyl-N-methyl-2-pyrrolidinemethanol
- Synonyms
- (S)-α,α-Diphenyl-N-methyl-2-pyrrolidinemethanol
Asymmetric Synthesis
Utilised as a chiral auxiliary or catalyst in stereoselective reactions to control the formation of specific enantiomers. Its structural features enable high levels of stereocontrol in various synthetic pathways.
Chiral Ligand Development
Serves as a precursor or component in the design and synthesis of novel chiral ligands for transition metal catalysis. These ligands are critical for enantioselective metal-catalyzed reactions.
Organocatalysis
Functions as a proline-derived organocatalyst in a range of organic transformations. Its efficacy in promoting reactions like Michael additions and aldol reactions is well-documented.
Research and Development
Employed in academic and industrial research laboratories for exploring new synthetic methodologies and developing complex chiral molecules. It is a staple reagent for chemists investigating stereochemistry.
| Molecular weight | 267.37 |
|---|---|
| Empirical formula | C18H21NO |
| Assay | ≥96.0% (sum of enantiomers, GC) |
| Optical activity | [α]20/D +55±3°, c = 1% in chloroform stab. with amylenes |
| Melting point | 66-72 °C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is α,α-Diphenyl-N-methyl-L-prolinol used for?
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α,α-Diphenyl-N-methyl-L-prolinol is primarily used in asymmetric synthesis, as a chiral ligand, and in organocatalysis for the development of enantiomerically pure compounds in research and chemical synthesis.
What is the CAS number and molecular formula for α,α-Diphenyl-N-methyl-L-prolinol?
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The CAS number is 110529-22-1, and the molecular formula is C18H21NO.
What grade and purity does Tech Serve Solutions supply for α,α-Diphenyl-N-methyl-L-prolinol?
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Tech Serve Solutions supplies α,α-Diphenyl-N-methyl-L-prolinol with a purity of ≥96.0% (sum of enantiomers, GC). We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should α,α-Diphenyl-N-methyl-L-prolinol be handled safely?
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Handle with appropriate personal protective equipment, including a dust mask (type N95 US), eyeshields, and gloves. Avoid inhalation of dust and contact with skin and eyes. Ensure good ventilation. Refer to the Safety Data Sheet for detailed handling instructions.
Is α,α-Diphenyl-N-methyl-L-prolinol shipped internationally?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including α,α-Diphenyl-N-methyl-L-prolinol, and can accommodate international orders.
How can I request a quote or sample for α,α-Diphenyl-N-methyl-L-prolinol?
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To request a quote or a sample, please contact our sales department via the website or direct email, providing your specific requirements and shipping details.
What are the GHS hazards associated with α,α-Diphenyl-N-methyl-L-prolinol?
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α,α-Diphenyl-N-methyl-L-prolinol carries GHS hazard statements H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). It is classified with the signal word 'Warning' and the symbol GHS07.
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