2-Hydroxy-5-nitrobenzyl bromide
2-Hydroxy-5-nitrobenzyl bromide (CAS: 772-33-8, HOC6H3(NO2)CH2Br) is a chemical compound with a molecular weight of 232.03. It serves as a valuable building block in organic synthesis, particularly for modifying biological molecules. This reagent is primarily utilised for the covalent modification of tryptophan and tryptophan residues in proteins and immunoglobulins, and for the modification of sulfhydryl groups. It is supplied with a minimum assay of 90%.
- IUPAC
- α-Bromo-4-nitro-o-cresol,2-Bromomethyl-4-nitrophenol,Koshland I,Koshland’s Reagent I
- Synonyms
- α-Bromo-4-nitro-o-cresol2-Bromomethyl-4-nitrophenolKoshland IKoshland’s Reagent I
Tryptophan Residue Modification
2-Hydroxy-5-nitrobenzyl bromide is employed for the covalent modification of tryptophan residues within proteins and monoclonal immunoglobulins. This application is crucial in biochemical research for studying protein structure and function.
Sulfhydryl Group Reagent
This compound functions as a specific reagent for the modification of sulfhydryl (-SH) groups. Such modifications are important in understanding protein chemistry and in the development of analytical methods.
Organic Synthesis Building Block
As an organic building block, 2-Hydroxy-5-nitrobenzyl bromide is used in the synthesis of more complex molecules. Its structure, featuring a nitro group and a reactive benzyl bromide moiety, allows for diverse chemical transformations.
| Molecular weight | 232.03 |
|---|---|
| Linear formula | HOC6H3(NO2)CH2Br |
| Assay | 90% |
| Solubility | chloroform: soluble25 mg/mL, clear, yellow |
| Storage temperature | 2-8°C |
| Application | 2-Hydroxy-5-nitrobenzyl bromide was used in covalent modification of tryptophan1 and tryptophan residues in monoclonal immunoglobulin2. It was also used as reagent for sulfhydryl modification3 |
| Melting point | 144-149 °C(lit.) |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 3261 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Hydroxy-5-nitrobenzyl bromide used for?
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2-Hydroxy-5-nitrobenzyl bromide is used for the covalent modification of tryptophan residues in proteins and immunoglobulins, and as a reagent for sulfhydryl modification in organic synthesis.
What is the CAS number and formula for 2-Hydroxy-5-nitrobenzyl bromide?
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The CAS number is 772-33-8, and the chemical formula is HOC6H3(NO2)CH2Br.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Hydroxy-5-nitrobenzyl bromide with a minimum assay of 90%. We do not represent this product as USP, BP, or EP grade.
How should 2-Hydroxy-5-nitrobenzyl bromide be handled?
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2-Hydroxy-5-nitrobenzyl bromide is classified as corrosive. Handle with appropriate personal protective equipment, including eyeshields, face shields, gloves, and a suitable respirator. Avoid contact with skin and eyes and ensure good ventilation. Refer to the Safety Data Sheet for detailed handling instructions.
How is 2-Hydroxy-5-nitrobenzyl bromide packed and shipped?
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This chemical is shipped as a dangerous good under UN 3261, Hazard Class 8, Packing Group II. Packaging adheres to regulatory requirements for safe transport.
How can I request a quote or sample?
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To request a quote or sample of 2-Hydroxy-5-nitrobenzyl bromide, please contact our sales department through the website or by phone, providing your requirements.
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