Dibutylchlorophosphine
Dibutylchlorophosphine (CAS 4323-64-2) is a key organophosphorus compound with the linear formula (CH3CH2CH2CH2)2PCl and a molecular weight of 180.66 g/mol. This reactive intermediate is primarily utilised in chemical synthesis, serving as a precursor for various phosphorus-containing molecules. Its applications span the preparation of phosphorus-substituted dialkylamides, participation in Lewis acid-catalyzed Diels-Alder reactions, and the synthesis of phosphinoalkynes through cross-coupling reactions.
- IUPAC
- Dibutylphosphinous chloride,NSC 203027
- Synonyms
- Dibutylphosphinous chlorideNSC 203027
Preparation of Phosphorus-Substituted Dialkylamides
Dibutylchlorophosphine acts as a crucial reactant in the synthesis of organophosphorus acids, specifically in forming phosphorus-substituted dialkylamides. This process leverages its reactive phosphorus-chlorine bond to introduce the dibutylphosphino group.
Lewis Acid Catalyzed Diels-Alder Reactions
This compound finds application as a participant in Diels-Alder reactions, particularly when catalysed by Lewis acids. It contributes to the formation of complex cyclic structures through cycloaddition pathways.
Synthesis of Phosphinoalkynes
Utilising palladium- and nickel-catalyzed cross-coupling reactions with terminal alkynes, Dibutylchlorophosphine is employed in the preparation of phosphinoalkynes, valuable building blocks in organic synthesis.
| Molecular weight | 180.66 |
|---|---|
| Linear formula | (CH3CH2CH2CH2)2PCl |
| Assay | ≥97.0% |
| Refractive index | n20/D 1.474 |
| Application | Reactant for:Preparationf of phosphorus-substituted dialkylamides of organophosphorus acids1Lewis acid catalyzed Diels-Alder reactions2Preparation of phosphinoalkynes via Pd- and Ni-catalyzed cross-coupling with terminal alkynes3 |
Hazard statements
- H250Catches fire spontaneously if exposed to air
- H314Causes severe skin burns and eye damage
Precautionary statements
- P222Do not allow contact with air
- P231Handle under inert gas
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
- P422
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Transport (UN / ADR) | UN 2845 4.2 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,C |
| Risk statements (R) | 17-34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Dibutylchlorophosphine used for?
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Dibutylchlorophosphine is used as a reactant in the preparation of phosphorus-substituted dialkylamides of organophosphorus acids, in Lewis acid-catalyzed Diels-Alder reactions, and for the preparation of phosphinoalkynes via cross-coupling reactions.
What are the CAS number and formula for Dibutylchlorophosphine?
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The CAS number for Dibutylchlorophosphine is 4323-64-2, and its linear formula is (CH3CH2CH2CH2)2PCl.
What grade and purity does Tech Serve Solutions supply for Dibutylchlorophosphine?
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Tech Serve Solutions supplies Dibutylchlorophosphine with a purity of ≥97.0%. We do not represent this product as meeting USP, BP, or EP pharmacopoeia standards.
How should Dibutylchlorophosphine be handled safely?
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Dibutylchlorophosphine is highly flammable and corrosive. It requires handling with extreme care, using appropriate personal protective equipment including face shields, gloves, goggles, and suitable respirators. It is pyrophoric and must be handled under an inert atmosphere.
How is Dibutylchlorophosphine packed and exported?
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Dibutylchlorophosphine is packed and exported in compliance with stringent safety regulations for hazardous materials, including UN 2845 classification for transport of pyrophoric solids, liquids, and gases.
How can I request a sample or quote for Dibutylchlorophosphine?
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To request a sample or a quote for Dibutylchlorophosphine, please contact the Tech Serve Solutions sales team through our website or by phone, providing your specific requirements.
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