Di-tert-butylchlorosilane
Di-tert-butylchlorosilane (CAS 56310-18-0), with the linear formula [(CH3)3C]2SiHCl and a molecular weight of 178.77 g/mol, is a silicon-based chemical reagent. This compound is primarily utilised in organic synthesis as a protecting and derivatizing agent. Its specific structure allows for selective reactions, making it valuable in multi-step synthetic pathways within chemical and pharmaceutical research.
- IUPAC
- Chloro-di-tert-butylsilane
![Di-tert-butylchlorosilane ([(CH3)3C]2SiHCl) — chemical structure, CAS 56310-18-0; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F56310-18-0.png&w=3840&q=75)
Protecting Group Reagent
Di-tert-butylchlorosilane serves as a reagent for introducing tert-butyldimethylsilyl (TBDMS) or related silyl protecting groups onto alcohols, amines, and other functional groups. This protection is reversible and crucial for preventing unwanted side reactions during complex syntheses.
Organic Synthesis Intermediate
The compound acts as a building block in the synthesis of more complex organosilicon compounds and other fine chemicals. Its reactivity allows for further functionalization, expanding its utility in research and development laboratories.
Derivatization Agent
In analytical chemistry, it can be used to derivatize analytes to improve their chromatographic properties or detectability. This is particularly useful for compounds that are otherwise difficult to analyse directly.
| Molecular weight | 178.77 |
|---|---|
| Linear formula | [(CH3)3C]2SiHCl |
| Assay | 99% |
| Boiling point | 82-84 °C/45 mmHg(lit.) |
| Density | 0.884 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.441(lit.) |
Hazard statements
- H226Flammable liquid and vapour
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 39 °C / 102.2 °F |
| Transport (UN / ADR) | UN 2986 3(8) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 10-34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Di-tert-butylchlorosilane used for?
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Di-tert-butylchlorosilane is primarily used as a protecting and derivatizing reagent in organic synthesis. It is employed to introduce silyl protecting groups onto various functional groups, facilitating multi-step synthetic processes.
What is the CAS number and formula for Di-tert-butylchlorosilane?
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The CAS number is 56310-18-0 and its linear formula is [(CH3)3C]2SiHCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Di-tert-butylchlorosilane with an assay of 99%. This product is supplied for laboratory and research use and is not represented as USP, BP, or EP grade.
How should Di-tert-butylchlorosilane be handled safely?
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Di-tert-butylchlorosilane is a flammable liquid and causes severe skin burns and eye damage (Danger, H226-H314). Handle with extreme care, wearing appropriate personal protective equipment including face shields, gloves, goggles, and a suitable respirator. Ensure adequate ventilation and avoid ignition sources.
How is Di-tert-butylchlorosilane packed and shipped?
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Di-tert-butylchlorosilane is shipped as a flammable liquid in accordance with UN 2986, Class 3(8), Packing Group II regulations. Our export team ensures compliance with all international shipping and handling requirements.
How can I request a quote or sample of Di-tert-butylchlorosilane?
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To request a quote or sample of Di-tert-butylchlorosilane, please contact our sales department through the website or by phone, providing your contact details and the required quantity.
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