5-Chloro-1-pentyne
5-Chloro-1-pentyne (CAS: 14267-92-6), with the linear formula HC≡CCH₂CH₂CH₂Cl and a molecular weight of 102.56 g/mol, is a versatile halogenated hydrocarbon. This alkynyl building block serves as a crucial intermediate in organic synthesis. Its primary applications include the preparation of organometallic compounds and the formation of heterocyclic structures like pyrazoles, making it valuable for research and development in chemical synthesis.
Organometallic Synthesis
5-Chloro-1-pentyne can be reacted with organometallic reagents, such as Me₃SnCu·Me₂S, to yield functionalized organostannanes, like 5-chloro-2-trimethylstannyl-1-pentene. This facilitates further synthetic transformations.
Heterocycle Formation
This compound participates in copper-catalyzed cyclisation reactions with α-diazoesters. This methodology provides an efficient route for the synthesis of substituted pyrazoles, important heterocyclic motifs.
Organic Building Block
As a bifunctional molecule containing both an alkyne and a primary alkyl chloride, 5-chloro-1-pentyne offers diverse reactivity. It serves as a valuable building block for constructing more complex organic molecules.
| Molecular weight | 102.56 |
|---|---|
| Linear formula | HC≡CCH2CH2CH2Cl |
| Assay | 98% |
| Boiling point | 67-69 °C/145 mmHg(lit.) |
| Density | 0.968 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.444(lit.) |
| Storage temperature | 2-8°C |
| Application | 5-Chloro-1-pentyne was used in the synthesis of 5-chloro-2-trimethylstannyl-1-pentene by reacting with Me3SnCu.Me2S1. It was also used with α-diazoesters in a copper-catalyzed synthesis of pyrazoles1. |
Hazard statements
- H225Highly flammable liquid and vapour
- H315Causes skin irritation
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 15 °C / 59 °F |
| Transport (UN / ADR) | UN 1993BF 3 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,Xi |
| Risk statements (R) | 11-38 |
| Safety statements (S) | 23-24/25 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-Chloro-1-pentyne used for?
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5-Chloro-1-pentyne is primarily used as a building block in organic synthesis, particularly for preparing organometallic compounds and for the synthesis of heterocyclic compounds such as pyrazoles.
What are the CAS number and formula for 5-Chloro-1-pentyne?
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The CAS number for 5-Chloro-1-pentyne is 14267-92-6, and its linear formula is HC≡CCH₂CH₂CH₂Cl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 5-Chloro-1-pentyne with an assay of 98%. This product is intended for research and synthesis and is not supplied as USP, BP, EP, or pharmaceutical grade.
How should 5-Chloro-1-pentyne be handled safely?
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5-Chloro-1-pentyne is a highly flammable liquid and vapour (H225) and causes skin irritation (H315). Handle with appropriate personal protective equipment, including eyeshields, gloves, and respiratory protection, in a well-ventilated area away from ignition sources. Store at 2-8°C.
Is 5-Chloro-1-pentyne packed and shipped internationally?
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Yes, Tech Serve Solutions can pack and export 5-Chloro-1-pentyne globally, adhering to all necessary shipping regulations for hazardous materials like UN 1993.
How can I request a quote or sample of 5-Chloro-1-pentyne?
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To request a quote or a sample of 5-Chloro-1-pentyne, please contact our sales department through the TSS website or by calling us directly.
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