DavePhos
DavePhos (CAS: 213697-53-1), with the molecular formula C26H36NP and a molecular weight of 393.54, is a specialized organophosphorus compound. It functions as a crucial ligand in palladium-catalyzed cross-coupling reactions. Its primary application is in facilitating Suzuki-Miyaura coupling for the synthesis of complex organic molecules, particularly in the development of benzodioxepines, and it is also valuable in Buchwald-Hartwig aminations and other C-N bond-forming reactions.
- IUPAC
- 2-Dicyclohexylphosphino-2′-(N,N-dimethylamino)biphenyl
Suzuki-Miyaura Coupling
DavePhos serves as an effective ligand in palladium-catalyzed Suzuki-Miyaura coupling reactions. This application is particularly noted for its utility in the synthesis of benzodioxepines.
Buchwald-Hartwig Amination
This ligand is employed in Buchwald-Hartwig amination reactions, a key method for forming carbon-nitrogen bonds. It facilitates the coupling of amines with aryl halides or pseudohalides.
Cross-Coupling Reactions
As a member of the Buchwald ligand family, DavePhos is broadly applicable in various palladium-catalyzed cross-coupling reactions, including Kumada and Negishi couplings, enabling the formation of carbon-carbon bonds.
Ligand for Arylations
DavePhos is utilized as a ligand in palladium-catalyzed arylations, contributing to the efficient construction of biaryl compounds and other complex aromatic systems.
| Molecular weight | 393.54 |
|---|---|
| Empirical formula | C26H36NP |
| Assay | 97% |
| Application | Ligand used in a Pd-catalyzed Suzuki aryl-aryl coupling leading to benzodioxepines.1 |
| Melting point | 121-124 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Ligand For | ArylationsBuchwald-Hartwig Cross Coupling ReactionHydroaminationsKumada CouplingNegishi CouplingSuzuki-Miyaura Coupling |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is DavePhos primarily used for?
+
DavePhos is primarily used as a ligand in palladium-catalyzed cross-coupling reactions, such as Suzuki-Miyaura coupling for benzodioxepine synthesis and Buchwald-Hartwig amination.
What are the CAS number and molecular formula for DavePhos?
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The CAS number for DavePhos is 213697-53-1, and its molecular formula is C26H36NP.
What grade and purity does Tech Serve Solutions supply for DavePhos?
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Tech Serve Solutions supplies DavePhos with a minimum assay of 97%. This product is intended for research and laboratory use and is not represented as USP, BP, EP, or pharmaceutical grade.
How should DavePhos be handled safely?
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DavePhos is a Warning substance (GHS07) that causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Handle with a dust mask (N95), eyeshields, and gloves in a well-ventilated area.
Is DavePhos available for international export?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including DavePhos, and can ship to numerous international destinations.
How can I request a sample or a quote for DavePhos?
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To request a sample or a quote for DavePhos, please contact our sales team through the website or by phone, providing your specific requirements and delivery details.
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