D-Cycloserine
D-Cycloserine (CAS: 68-41-7), with the molecular formula C3H6N2O2 and a molecular weight of 102.09 g/mol, is a structural analogue of D-alanine. This compound functions as a competitive inhibitor of bacterial cell wall synthesis, targeting enzymes like alanine racemase and D-alanyl-D-alanine ligase. It is primarily recognised for its use as an antibacterial agent, specifically in the treatment of multidrug-resistant tuberculosis, and also finds application in biochemical research for enzyme inhibition studies.
- IUPAC
- (R)-4-Amino-3-isoxazolidone,4-Amino-3-isoxazolidinone
- Synonyms
- 4-Amino-3-isoxazolidinone(R)-4-amino-3-isoxazolidinone
Antibacterial Agent
D-Cycloserine is clinically used as a second-line antibiotic for treating multidrug-resistant tuberculosis (MDR-TB). It inhibits bacterial cell wall synthesis by interfering with the formation of peptidoglycans, specifically by acting as a suicide inhibitor of alanine racemase and D-alanyl-D-alanine ligase.
Enzyme Inhibition in Research
In biochemical research, D-Cycloserine serves as a tool to study enzymes involved in amino acid metabolism and cell wall biosynthesis. Its mechanism as a specific inhibitor allows researchers to elucidate the functions of these enzymes in various biological pathways and microbial processes.
Amino Acid Derivative Studies
As an amino acid derivative, D-Cycloserine is utilised in studies concerning protein synthesis and related biochemical pathways. Its unique cyclic structure and inhibitory properties make it valuable for understanding enzyme mechanisms and substrate interactions in organic synthesis and medicinal chemistry.
| Molecular weight | 102.09 |
|---|---|
| Empirical formula | C3H6N2O2 |
| Assay | ≥96.0% (NT) |
| Solubility | 0.1 M phosphate pH 8.0: soluble10 mg/mL (as a stock solution) |
| Optical activity | [α]20/D +115.0±5.0°, c = 2% in H2O |
| Storage temperature | −20°C |
| Application | Cycloserine is used to inhibit various enzymes. |
| Melting point | 147 °C (dec.)(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 2 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Sterility | γ-irradiated |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is D-Cycloserine used for?
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D-Cycloserine is used as an antibacterial agent, particularly for multidrug-resistant tuberculosis, and in biochemical research for enzyme inhibition studies.
What is the CAS number and formula for D-Cycloserine?
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The CAS number for D-Cycloserine is 68-41-7, and its molecular formula is C3H6N2O2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies D-Cycloserine with an assay of ≥96.0% (NT). This product is not represented as USP, BP, EP, or pharmacopoeia grade.
How should D-Cycloserine be handled and stored?
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Handle D-Cycloserine with appropriate personal protective equipment, including eyeshields, gloves, and a type N95 respirator filter. Store at -20°C. It is supplied as gamma-irradiated for sterility.
How is D-Cycloserine shipped and exported?
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Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including D-Cycloserine, ensuring compliance with international shipping regulations.
How can I request a quote or sample of D-Cycloserine?
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To request a quote or sample of D-Cycloserine, please contact the Tech Serve Solutions sales team through our official channels.
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