Cyclosporin A
Cyclosporin A (CAS: 59865-13-3), with the empirical formula C62H111N11O12 and a molecular weight of 1202.61 g/mol, is a potent immunosuppressive antibiotic. It functions by inhibiting calcineurin, a key enzyme in T-cell activation. This mechanism makes it invaluable in research settings for studying immune responses and transplantation science. Its applications extend to research into autoimmune diseases and certain types of cancer.
- IUPAC
- Antibiotic S 7481F1,Cyclosporine
- Synonyms
- CyclosporineCyclo-L-Pro-L-N-MeLeu-D-Ala-L-N-MeLeu-L-Ala-L-N-MeLeu-L-Pro-L-Gln-L-N-MeLeu-D-N-MeVal-L-N-MeLeu
Immunosuppressive Studies
Cyclosporin A is widely employed in research to investigate the mechanisms of immunosuppression. Its ability to modulate T-cell activity is crucial for understanding immune system regulation and dysfunction.
Transplantation Research
In the field of transplantation, Cyclosporin A serves as a vital tool for studying graft rejection processes and the efficacy of immunosuppressive therapies. It helps researchers explore strategies to improve transplant outcomes.
Autoimmune Disease Research
Its immunosuppressive properties make Cyclosporin A a relevant compound for researching the pathogenesis and potential treatments for autoimmune disorders, where the immune system mistakenly attacks the body's own tissues.
Oncology Studies
Cyclosporin A has applications in cancer research, particularly in understanding its role in antineoplastic and immunosuppressive therapies. It is used to explore its effects in various cancer models.
| Molecular weight | 1202.61 |
|---|---|
| Empirical formula | C62H111N11O12 |
| Assay | ≥95% (HPLC) |
| Solubility | dichloromethane: soluble10 mg/mLethanol: soluble10 mg/mLDMSO: soluble50 mg/mLchloroform: soluble6 mg/mLH2O: insoluble |
| Storage temperature | 2-8°C |
| Application | Cyclosporin A is used for immunosuppressive studies 1,2. |
Hazard statements
- H302Harmful if swallowed
- H350May cause cancer
- H360May damage fertility or the unborn child
Precautionary statements
- P201Obtain special instructions before use
- P308IF exposed or concerned
| Protective equipment | Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 45-60-22 |
| Safety statements (S) | 53-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Cyclosporin A used for?
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Cyclosporin A is used for immunosuppressive studies, including research in transplantation, autoimmune diseases, and oncology. It functions by inhibiting calcineurin, which plays a critical role in T-cell activation.
What are the CAS number and formula for Cyclosporin A?
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The CAS number for Cyclosporin A is 59865-13-3, and its empirical formula is C62H111N11O12.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Cyclosporin A with an assay of ≥95% (HPLC). We do not represent this product as USP, BP, or EP grade.
What are the safety and handling precautions for Cyclosporin A?
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Cyclosporin A is classified as Danger, with hazards including H302 (Harmful if swallowed), H350 (May cause cancer), and H360 (May damage fertility or the unborn child). Appropriate personal protective equipment, including eyeshields, gloves, and respiratory protection (type N100 or P3), is essential. Handle with extreme caution in a well-ventilated area, following all safety guidelines.
How is Cyclosporin A packed and shipped?
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Cyclosporin A is typically stored at 2-8°C. It is carefully packed for shipment, adhering to all regulations for the export of chemical reagents.
How can I request a quote or sample for Cyclosporin A?
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To request a quote or a sample of Cyclosporin A, please contact our sales team through the website or by phone. We will be pleased to assist you with your research needs.
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