Cyclopropylboronic acid pinacol ester
Cyclopropylboronic acid pinacol ester (CAS: 126689-01-8, C9H17BO2) is an organoboron compound with a molecular weight of 168.04. This versatile reagent is characterised by its stability and reactivity, finding significant utility in organic synthesis. It serves as a valuable building block in cross-coupling reactions, particularly Suzuki-Miyaura couplings, for the construction of complex organic molecules. Its applications span pharmaceutical research and the development of novel materials.
- IUPAC
- 2-Cyclopropyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
- Synonyms
- 2-Cyclopropyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
Suzuki-Miyaura Cross-Coupling
Cyclopropylboronic acid pinacol ester is extensively employed as a coupling partner in Suzuki-Miyaura reactions. It facilitates the formation of carbon-carbon bonds, enabling the synthesis of biaryl compounds and other complex structures relevant to medicinal chemistry and materials science.
Organic Synthesis Intermediate
This organoboron compound acts as a key intermediate in multi-step organic syntheses. Its cyclopropyl moiety can be introduced into various molecular frameworks, offering unique structural and electronic properties.
Pharmaceutical Research
The compound is utilised in the synthesis of potential drug candidates and active pharmaceutical ingredients (APIs). The incorporation of the cyclopropyl group can modulate pharmacokinetic properties and biological activity.
Material Science
Cyclopropylboronic acid pinacol ester can be used in the development of new organic materials, such as polymers or functional molecules, where the cyclopropyl group imparts specific physical or chemical characteristics.
| Molecular weight | 168.04 |
|---|---|
| Empirical formula | C9H17BO2 |
| Assay | 96% |
| Boiling point | 146 °C |
| Density | 0.922 g/mL at 25 °C |
| Refractive index | n20/D 1.433 |
Hazard statements
- H226Flammable liquid and vapour
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 40 °C / 104 °F |
| Transport (UN / ADR) | UN 3272 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Risk statements (R) | 10 |
| Safety statements (S) | 16 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Cyclopropylboronic acid pinacol ester used for?
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Cyclopropylboronic acid pinacol ester is primarily used as a reagent in organic synthesis, particularly for Suzuki-Miyaura cross-coupling reactions. It serves as a building block for creating complex organic molecules, with applications in pharmaceutical research and material science.
What is the CAS number and chemical formula for Cyclopropylboronic acid pinacol ester?
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The CAS number for Cyclopropylboronic acid pinacol ester is 126689-01-8, and its chemical formula is C9H17BO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Cyclopropylboronic acid pinacol ester with an assay of 96%. We do not represent this product as USP, BP, EP, or other pharmacopoeial grades.
How should Cyclopropylboronic acid pinacol ester be handled safely?
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Cyclopropylboronic acid pinacol ester is a flammable liquid and vapour (H226). Handle with appropriate personal protective equipment, including eyeshields, gloves, and suitable respiratory protection, in a well-ventilated area. Keep away from heat, hot surfaces, sparks, and open flames.
How is Cyclopropylboronic acid pinacol ester packed and shipped?
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Cyclopropylboronic acid pinacol ester is packed and shipped in compliance with regulations for flammable liquids (UN 3272, Class 3, PGIII). We are a specialist global supplier and exporter of fine chemicals.
How can I request a quote or sample?
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To request a quote or sample of Cyclopropylboronic acid pinacol ester, please contact our sales team via the website or direct telephone number.
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