Cyclopiazonic acid from Penicillium cyclopium

CAS 18172-33-3C20H20N2O3Cell Biology

Cyclopiazonic acid (CAS: 18172-33-3), with the molecular formula C20H20N2O3 and a molecular weight of 336.38 g/mol, is a mycotoxin produced by certain species of fungi, notably Penicillium cyclopium. This white to off-white powder is primarily utilised in biochemical research for its ability to inhibit the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) pump, a crucial component in intracellular calcium regulation and signalling. It serves as a valuable tool for studying calcium homeostasis.

IUPAC: CPA
Synonyms: CI-CY

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Cyclopiazonic acid from Penicillium cyclopium (C20H20N2O3) — chemical structure, CAS 18172-33-3; Life Science, fine chemical supplied by Tech Serve Solutions

Bioactive Small MoleculesCI-CYCell Biology

01 /Applications

Intracellular Calcium Signalling Research

Cyclopiazonic acid is extensively used as a pharmacological tool to inhibit SERCA pumps. This inhibition leads to increased cytosolic calcium levels and depletion of ER calcium stores, making it invaluable for studying calcium dynamics and signalling pathways in various cell types.

Cell Biology Studies

Researchers employ Cyclopiazonic acid to investigate the role of SERCA pumps in cellular processes such as muscle contraction, neurotransmitter release, and apoptosis. Its specific mechanism of action allows for targeted investigation of calcium-dependent cellular functions.

Neuroscience Research

In neuroscience, Cyclopiazonic acid helps elucidate the impact of impaired calcium handling on neuronal function and excitability. It aids in understanding the complex interplay between calcium homeostasis and neurological processes.

02 /Properties

Molecular weight	336.38
Empirical formula	C20H20N2O3
Assay	≥98% (HPLC)
Form	powder
Colour	white to off-white
Solubility	DMSO: solublechloroform: soluble
Storage temperature	−20°C

03 /Safety & handling

GHS hazard pictogram: Toxic (GHS06) — Toxic

Danger

Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash thoroughly after handling
P301IF SWALLOWED

Protective equipment	Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Transport (UN / ADR)	UN 2811 6.1 / PGII
Water hazard class (WGK, DE)	3
Hazard codes (EU)	T
Risk statements (R)	25
Safety statements (S)	36/37/39-45

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

18172-33-3

MDL number

MFCD00167445

PubChem substance

24892420

05 /Additional specifications

Gene Information	human ... ADORA1(134), ADORA2A(135), ADORA3(140)mouse ... Adora1(11539)rat ... Adora1(29290), Adora2a(25369), Adora3(25370)

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is Cyclopiazonic acid used for?

Cyclopiazonic acid is used in biochemical and cell biology research to inhibit the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) pump, thereby studying intracellular calcium regulation and signalling.

What are the CAS number and formula for Cyclopiazonic acid?

The CAS number for Cyclopiazonic acid is 18172-33-3, and its empirical formula is C20H20N2O3.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Cyclopiazonic acid with a purity of ≥98% (HPLC). TSS does not represent this product as USP, BP, EP, or any other pharmacopoeia grade.

How should Cyclopiazonic acid be handled safely?

Cyclopiazonic acid is classified as Danger with hazard statement H300 (Fatal if swallowed). Appropriate personal protective equipment, including eyeshields, face shields, gloves, and P2 respirator cartridges, must be used. Handle in a well-ventilated area and follow all safety precautions outlined in the Safety Data Sheet.

How is Cyclopiazonic acid packed, shipped, and exported?

Cyclopiazonic acid is typically supplied as a powder and stored at -20°C. Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, adhering to all relevant shipping and export regulations.

How can I request a quote or sample for Cyclopiazonic acid?

To request a quote or sample of Cyclopiazonic acid, please contact our sales team through the website or by phone, providing your specific requirements and delivery details.