Colistin sodium methanesulfonate

CAS 8068-28-8C58H115N16Na5O28S5Biochemicals & Reagents

Colistin sodium methanesulfonate (CAS: 8068-28-8), with the molecular formula C58H115N16Na5O28S5 and a molecular weight of 1759.90 g/mol, is a derivative of colistin, an antibiotic. It functions by permeabilizing bacterial cell membranes. This compound is utilised in research to study effective treatments for infections, particularly those caused by *P. aeruginosa*, and to investigate its pharmacokinetics and tissue distribution in critically ill patients.

IUPAC: Colimycin sodium methanesulfonate,Methanesulfonic acid derivative of Polymyxin E,Polymyxin E sodium methanesulfonate
Synonyms: Colimycin sodium methanesulfonateMethanesulfonic acid derivative of Polymyxin EPolymyxin E sodium methanesulfonate

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Colistin sodium methanesulfonate (C58H115N16Na5O28S5) — chemical structure, CAS 8068-28-8; Life Science, fine chemical supplied by Tech Serve Solutions

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01 /Applications

Bacterial Cell Membrane Permeabilization

Colistin sodium methanesulfonate is employed in laboratory settings to induce permeability in bacterial cell membranes. This allows for the study of cellular processes and the effects of various agents on bacterial integrity.

Antibiotic Research

This compound serves as a tool for researching antibiotic efficacy, particularly against Gram-negative bacteria like *P. aeruginosa*. Its use in studies aids in understanding treatment strategies for infections in conditions such as cystic fibrosis.

Pharmacokinetic Studies

Researchers utilise colistin sodium methanesulfonate to investigate its pharmacokinetic profile and penetration into specific tissues, such as bronchoalveolar lavage fluid (BAL). This is crucial for understanding drug distribution in critically ill patients.

Mannose-Resistant Haemagglutination Studies

The compound is applied in the investigation of mannose-resistant haemagglutination, a phenomenon relevant in understanding bacterial adhesion and pathogenicity.

02 /Properties

Molecular weight	1759.90
Empirical formula	C58H115N16Na5O28S5
pH	6-8 (10 mg/mL in H2O)
Loss on drying	≤1.5% loss on drying
Storage temperature	2-8°C
Application	Colistin sodium methanesulfate is used to permeabilize bacterial cell membranes and to study mannose-resistant haemagglutination. It is used to study effective treatments of P. aeruginosa infections in cystic fibrosis patients 1 and to study the pharmacokinetics and BAL concentration of colistin in critically ill patients 2.
Biological source	from Bacillus colistinus

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	2
Ignition residue	~20%

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

8068-28-8

MDL number

MFCD00130824

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Colistin sodium methanesulfonate used for?

Colistin sodium methanesulfonate is used to permeabilize bacterial cell membranes and in research to study mannose-resistant haemagglutination, effective treatments for *P. aeruginosa* infections, and the pharmacokinetics of colistin in critically ill patients.

What is the CAS number and formula for Colistin sodium methanesulfonate?

The CAS number for Colistin sodium methanesulfonate is 8068-28-8, and its empirical formula is C58H115N16Na5O28S5.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Colistin sodium methanesulfonate as a research-grade chemical. The exact purity and assay are detailed in the product specifications. We do not represent this product as USP, BP, or EP grade unless explicitly stated in the specification.

How should Colistin sodium methanesulfonate be handled and stored?

Handle Colistin sodium methanesulfonate with appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. Store the compound at 2-8°C.

Is Colistin sodium methanesulfonate a controlled substance?

The provided data does not indicate that Colistin sodium methanesulfonate is a controlled substance. It is classified with WGK Germany 2.

How can I request a quote or sample for Colistin sodium methanesulfonate?

To request a quote or sample of Colistin sodium methanesulfonate, please contact our sales team through the website or via email, providing your specific requirements and contact information.

How is Colistin sodium methanesulfonate packaged and shipped?

Colistin sodium methanesulfonate is typically packaged according to industry standards for chemical reagents and is available for global export. Specific packaging details can be provided upon request.