2-Nitroimidazole
2-Nitroimidazole (CAS: 527-73-1, Formula: C3H3N3O2) is a vital heterocyclic organic compound with a molecular weight of 113.07. As a key building block in chemical synthesis, it finds application in the development of various research chemicals and potential pharmaceutical precursors. Its structure lends itself to modifications for targeted applications, particularly in areas requiring specific biological interactions or imaging capabilities.
- IUPAC
- Azomycin
- Synonyms
- Azomycin
Synthesis of Pharmaceutical Intermediates
Used in the creation of advanced intermediates such as tert-butyl 2-(2-nitro-1H-imidazol-1-yl)ethylcarbamate and 2-fluoro-N-(2-(2-nitro-1H-imidazol-1-yl)ethyl)acetamide, valuable for drug discovery research.
Radiopharmaceutical Precursor Development
Serves as a precursor for radiolabeling, specifically involving bromo-substituted analogues, and the synthesis of nitroimidazole substituted boronic acids for imaging hypoxic tissues.
Development of Radiosensitizers
Investigated for its potential role in creating site-selective radiosensitizers targeting estrogen receptor-rich tumours, contributing to advancements in cancer therapy research.
Organic Synthesis Building Block
A versatile C3 building block utilized in heterocyclic chemistry for constructing more complex molecular architectures in research and development settings.
| Molecular weight | 113.07 |
|---|---|
| Empirical formula | C3H3N3O2 |
| Assay | ≥98.0% (HPLC) |
| Application | 2-Nitroimidazole was used in the synthesis of:• tert-butyl 2-(2-nitro-1H-imidazol-1-yl)ethylcarbamate1• 1-(2-(tert-butyldimethylsilyloxy)ethyl)-2-nitro-1H-imidazole1• 2-fluoro-N-(2-(2-nitro-1H-imidazol-1-yl)ethyl)acetamide1• 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl 2-fluoroacetate1• radiolabeling precursors - the bromo substituted analogs1 • nitroimidazole substituted boronic acids, precursors for imaging hypoxic tissue2 • potential site-selective radiosensitizers for estrogen receptor-rich tumors3 |
| Melting point | 287 °C (dec.)(lit.) |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Transport (UN / ADR) | UN 2811 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Nitroimidazole used for?
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2-Nitroimidazole is primarily used as a building block in organic synthesis, particularly for developing pharmaceutical intermediates, radiolabeling precursors for imaging hypoxic tissues, and potential radiosensitizers for cancer research.
What are the CAS number and formula for 2-Nitroimidazole?
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The CAS number for 2-Nitroimidazole is 527-73-1, and its chemical formula is C3H3N3O2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Nitroimidazole with an assay of ≥98.0% (HPLC). We do not represent this product as USP, BP, EP, or other pharmacopoeia grades unless explicitly stated.
How should 2-Nitroimidazole be handled safely?
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2-Nitroimidazole is classified as harmful if swallowed, causes skin irritation, causes serious eye irritation, and may cause respiratory irritation. Appropriate personal protective equipment, including a dust mask (type N95), eyeshields, faceshields, and gloves, should be used. Ensure adequate ventilation.
Is 2-Nitroimidazole a controlled substance?
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The provided data does not indicate that 2-Nitroimidazole is a controlled substance.
How is 2-Nitroimidazole packed and shipped by TSS?
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Tech Serve Solutions, as a specialist global supplier and exporter of fine chemicals, ensures appropriate packaging and handling for international shipment of 2-Nitroimidazole in compliance with relevant regulations.
How can I request a sample or quote for 2-Nitroimidazole?
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Please contact our sales team through the website or direct inquiry channels to request a sample or a quotation for 2-Nitroimidazole.
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